Type 2 Diabetes Mellitus Drugs for Alzheimer's Disease: Current Evidence and Therapeutic Opportunities

被引：41
作者：
Meng, Lei [1 ,2 ]
Li, Xin-Yu [1 ,2 ]
Shen, Liang [1 ,2 ]
Ji, Hong-Fang [1 ,2 ]
机构：
[1] Shandong Univ Technol, Inst Biomed Res, Zibo, Shandong, Peoples R China
[2] Shandong Univ Technol, Shandong Prov Res Ctr Bioinformat Engn & Tech, Sch Life Sci, Zibo Key Lab New Drug Dev Neurodegenerat Dis, Zibo, Shandong, Peoples R China
来源：
TRENDS IN MOLECULAR MEDICINE | 2020年 / 26卷 / 06期
关键词：
AMYLOID-BETA-PROTEIN; GAMMA AGONIST PIOGLITAZONE; MILD COGNITIVE IMPAIRMENT; MODULATING TAU HYPERPHOSPHORYLATION; DIPEPTIDYL PEPTIDASE-4 INHIBITOR; MOUSE MODEL; MEMORY IMPAIRMENT; INTRANASAL INSULIN; RECEPTOR AGONIST; PPAR-GAMMA;
D O I：
10.1016/j.molmed.2020.02.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) represent two major health burdens with steadily increasing prevalence and accumulating evidence indicates a close relationship between the two disorders. In view of their similar pathogenesis, the potential of T2DM drugs for the treatment of AD has attracted considerable attention in recent years, with inspiring outcomes. Here, we provide a comprehensive overview of the effects of a total of 14 individual drugs (among which are seven T2DM drug types) against AD. Further, we discuss the potential action mechanisms of these T2DM drugs against AD. We argue that these findings may open novel avenues for AD drug discovery, drug target identification, and cotreatment of the two disorders.
引用
收藏
页码：597 / 614
页数：18
相关论文
共 114 条
[11]   Metformin attenuates diabetes-induced tau hyperphosphorylation in vitro and in vivo by enhancing autophagic clearance [J].
Chen, Jin-Liang ;
Luo, Cheng ;
Pu, Die ;
Zhang, Guo-Qiang ;
Zhao, Yu-Xing ;
Sun, Yue ;
Zhao, Ke-Xiang ;
Liao, Zhi-Yin ;
Lv, An-Kang ;
Zhu, Shi-Yu ;
Zhou, Jing ;
Xiao, Qian .
EXPERIMENTAL NEUROLOGY, 2019, 311 :44-56
[12]   Anti-Diabetes Drug Pioglitazone Ameliorates Synaptic Defects in AD Transgenic Mice by Inhibiting Cyclin-Dependent Kinase5 Activity [J].
Chen, Jinan ;
Li, Shenghua ;
Sun, Wenshan ;
Li, Junrong .
PLOS ONE, 2015, 10 (04)
[13]   Liraglutide Improves Water Maze Learning and Memory Performance While Reduces Hyperphosphorylation of Tau and Neurofilaments in APP/PS1/Tau Triple Transgenic Mice [J].
Chen, Shuyi ;
Sun, Jie ;
Zhao, Gang ;
Guo, Ai ;
Chen, Yanlin ;
Fu, Rongxia ;
Deng, Yanqiu .
NEUROCHEMICAL RESEARCH, 2017, 42 (08) :2326-2335
[14]   Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease by exendin-4 [J].
Chen, Song ;
Liu, Ai-ran ;
An, Feng-mao ;
Yao, Wen-bing ;
Gao, Xiang-dong .
AGE, 2012, 34 (05) :1211-1224
[15]   Sex and ApoE Genotype Differences in Treatment Response to Two Doses of Intranasal Insulin in Adults with Mild Cognitive Impairment or Alzheimer's Disease [J].
Claxton, Amy ;
Baker, Laura D. ;
Wilkinson, Charles W. ;
Trittschuh, Emily H. ;
Chapman, Darla ;
Watson, G. Stennis ;
Cholerton, Brenna ;
Plymate, Stephen R. ;
Arbuckle, Matthew ;
Craft, Suzanne .
JOURNAL OF ALZHEIMERS DISEASE, 2013, 35 (04) :789-797
[16]   Brain-derived neurotrophic factor is reduced in Alzheimer's disease [J].
Connor, B ;
Young, D ;
Yan, Q ;
Faull, RLM ;
Synek, B ;
Dragunow, M .
MOLECULAR BRAIN RESEARCH, 1997, 49 (1-2) :71-81
[17]   Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer's Disease Biomarkers: A Pilot Clinical Trial [J].
Craft, Suzanne ;
Claxton, Amy ;
Baker, Laura D. ;
Hanson, Angela J. ;
Cholerton, Brenna ;
Trittschuh, Emily H. ;
Dahl, Deborah ;
Caulder, Erin ;
Neth, Bryan ;
Montine, Thomas J. ;
Jung, Youngkyoo ;
Maldjian, Joseph ;
Whitlow, Christopher ;
Friedman, Seth .
JOURNAL OF ALZHEIMERS DISEASE, 2017, 57 (04) :1325-1334
[18]   Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment A Pilot Clinical Trial [J].
Craft, Suzanne ;
Baker, Laura D. ;
Montine, Thomas J. ;
Minoshima, Satoshi ;
Watson, G. Stennis ;
Claxton, Amy ;
Arbuckle, Matthew ;
Callaghan, Maureen ;
Tsai, Elaine ;
Plymate, Stephen R. ;
Green, Pattie S. ;
Leverenz, James ;
Cross, Donna ;
Gerton, Brooke .
ARCHIVES OF NEUROLOGY, 2012, 69 (01) :29-38
[19]   Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice [J].
D'Amico, Michele ;
Di Filippo, Clara ;
Marfella, Raffaele ;
Abbatecola, Angela Maria ;
Ferraraccio, Franca ;
Rossi, Francesco ;
Paolisso, Giuseppe .
EXPERIMENTAL GERONTOLOGY, 2010, 45 (03) :202-207
[20]  
de la Monte Suzanne M, 2008, J Diabetes Sci Technol, V2, P1101
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