Drug-loaded electrospun mats of poly(vinyl alcohol) fibres and their release characteristics of four model drugs

被引：321
作者：
Taepaiboon, Pattama
Rungsardthong, Uracha
Supaphol, Pitt [1 ]
机构：
[1] Chulalongkorn Univ, Technol Ctr Electrospun Fibers, Bangkok 10330, Thailand
[2] Chulalongkorn Univ, Petr & Petr Coll, Bangkok 10330, Thailand
[3] Natl Nanotechnol Ctr, Klongluang 12120, Pathumthani, Thailand
来源：
NANOTECHNOLOGY | 2006年 / 17卷 / 09期
关键词：
D O I：
10.1088/0957-4484/17/9/041
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Mats of PVA nanofibres were successfully prepared by the electrospinning process and were developed as carriers of drugs for a transdermal drug delivery system. Four types of non-steroidal anti-inflammatory drug with varying water solubility property, i.e. sodium salicylate (freely soluble in water), diclofenac sodium (sparingly soluble in water), naproxen (NAP), and indomethacin (IND) (both insoluble in water), were selected as model drugs. The morphological appearance of the drug-loaded electrospun PVA mats depended on the nature of the model drugs. The H-1-nuclear magnetic resonance results confirmed that the electrospinning process did not affect the chemical integrity of the drugs. Thermal properties of the drug-loaded electrospun PVA mats were analysed by differential scanning calorimetry and thermogravimetric analysis. The molecular weight of the model drugs played a major role on both the rate and the total amount of drugs released from the as-prepared drug-loaded electrospun PVA mats, with the rate and the total amount of the drugs released decreasing with increasing molecular weight of the drugs. Lastly, the drug-loaded electrospun PVA mats exhibited much better release characteristics of the model drugs than drug-loaded as-cast films.
引用
收藏
页码：2317 / 2329
页数：13
相关论文
共 50 条
[21]   Preparation and characterization of polycaprolactone/diclofenac sodium and poly(vinyl alcohol)/tetracycline hydrochloride fiber mats and their release of the model drugs [J].
Kanawung, Kamonrat ;
Panitchanapan, Kanokwan ;
Puangmalee, Siri-orn ;
Utok, Witchuporn ;
Kreua-Ongarjnukool, Narumol ;
Rangkupan, Ratthapol ;
Meechaisue, Chidchanok ;
Supaphol, Pitt .
POLYMER JOURNAL, 2007, 39 (04) :369-378
[22]   Preparation and Characterization of Polycaprolactone/Diclofenac Sodium and Poly(vinyl alcohol)/Tetracycline Hydrochloride Fiber Mats and Their Release of the Model Drugs [J].
Kamonrat Kanawung ;
Kanokwan Panitchanapan ;
Siri-orn Puangmalee ;
Witchuporn Utok ;
Narumol Kreua-ongarjnukool ;
Ratthapol Rangkupan ;
Chidchanok Meechaisue ;
Pitt Supaphol .
Polymer Journal, 2007, 39 :369-378
[23]   Drug-loaded emulsion electrospun nanofibers: characterization, drug release and in vitro biocompatibility [J].
Hu, Jue ;
Prabhakaran, Molamma P. ;
Tian, Lingling ;
Ding, Xin ;
Ramakrishna, Seeram .
RSC ADVANCES, 2015, 5 (121) :100256-100267
[24]   A Review of the Release Profiles and Efficacies of Chemotherapy Drug-Loaded Electrospun Membranes [J].
Lin, Zhenyu ;
Chen, Hao ;
Xu, Jiawei ;
Wang, Jie ;
Wang, Huijing ;
Huang, Shifen ;
Xu, Shanshan .
POLYMERS, 2023, 15 (02)
[25]   Electrospun, sepiolite-loaded poly(vinyl alcohol)/soy protein isolate nanofibers: Preparation, characterization, and their drug release behavior [J].
Gutschmidt, David ;
Hazra, Raj Shankar ;
Zhou, Xiaoyi ;
Xu, Xuezhu ;
Sabzi, Mohammad ;
Jiang, Long .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 594
[26]   Drug-Loaded Polymeric Particulated Systems for Ophthalmic Drugs Release [J].
Mihailovici, Ruxandra ;
Croitoriu, Alexandra ;
Nedeff, Florin ;
Nedeff, Valentin ;
Ochiuz, Lacramioara ;
Vasincu, Decebal ;
Popa, Ovidiu ;
Agop, Maricel ;
Moraru, Andreea ;
Costin, Danut ;
Costuleanu, Marcel ;
Verestiuc, Liliana .
MOLECULES, 2022, 27 (14)
[27]   Superhydrophobic coating to delay drug release from drug-loaded electrospun fibrous materials [J].
Song, Botao ;
Xu, Shichen ;
Shi, Suqing ;
Jia, Pengxiang ;
Xu, Qing ;
Hu, Gaoli ;
Zhang, Hongxin ;
Wang, Cuiyu .
APPLIED SURFACE SCIENCE, 2015, 359 :245-251
[28]   Chemical structure of antibiotics determines their release rate from drug-loaded poly(vinyl alcohol)/sodium sulfated alginate nanofibrous wound dressings [J].
Gachi, Maryam Zare ;
Solouk, Atefeh ;
Shafieian, Mehdi ;
Daemi, Hamed .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 307
[29]   Poly(vinyl alcohol)-based electrospun nanofibers for the sustained release of celecoxib: Characterization and evaluation of drug release mechanism [J].
Dinari, Mohammad ;
Bina, Fateme ;
Khayamian, Taghi .
POLYMER COMPOSITES, 2018, 39 :E221-E227
[30]   Poly(vinyl alcohol) hydrogels as hydrophilic matrices for the release of lipophilic drugs loaded in PLGA nanoparticles [J].
Cascone, MG ;
Zhu, ZH ;
Borselli, F ;
Lazzeri, L .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2002, 13 (01) :29-32
12345