A New [2+2+1] Heterocyclization for the Synthesis of 2,3,5-Trisubstituted Thiophenes under Microwave Irradiation

被引：5
|
作者：
Xu, Hai-Wei
Ma, Guan-Hua
Jiang, Bo [1 ]
Tu, Shu-Jiang
机构：
[1] Jiangsu Normal Univ, Sch Chem & Chem Engn, Xuzhou 221116, Jiangsu, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2013年 / 45卷 / 24期
基金：
美国国家科学基金会;
关键词：
heterocyclization; substituted thiophene; three-component reactions; -thiocyanato ketone; 3-(2-aryl-2-oxoethylidene)-2-oxindole; SUBSTITUTED THIOPHENES; MOLECULAR DESIGN;
D O I：
10.1055/s-0033-1339917
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new three-component strategy for the efficient synthesis of 2,3,5-trisubstituted thiophene derivatives through a [2+2+1] heterocyclization between 3-(2-aryl-2-oxoethylidene)-2-oxindoles and -thiocyanato ketones under microwave irradiation is described. The bond-forming efficiency, accessibility, and generality of this synthesis make it highly valuable to assemble thiophene scaffolds.
引用
收藏
页码：3392 / 3398
页数：7
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