Synthesis of 3-Substituted 2-Aminonaphtho[2,3-b]furan-4,9-diones from 2-Hydroxy-1,4-Naphthoquinone and Nitroalkenes

被引：10

作者：

Zanwar, Manoj R. ^{[1
]}

Kavala, Veerababurao ^{[1
]}

Gawande, Sachin D. ^{[1
]}

Kuo, Chun-Wei ^{[1
]}

Kuo, Ting-Shen ^{[1
]}

Chen, Mei-Ling ^{[1
]}

He, Chiu-Hui ^{[1
]}

Yao, Ching-Fa ^{[1
]}

机构：

[1] Natl Taiwan Normal Univ, Dept Chem, Taipei 116, Taiwan

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 36期

关键词：

Multicomponent reactions; Green chemistry; Quinones; Nitroalkenes; Amines; ORGANIC-REACTIONS; CATALYST-FREE; WATER CHEMISTRY; DERIVATIVES; FURANONAPHTHOQUINONES; CONSTITUENTS; CYTOTOXICITY; SUPPRESSION; DECOMPOSITA; ALKYLATION;

D O I：

10.1002/ejoc.201300996

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The efficient base-catalyzed synthesis of 3-substituted 2-aminonaphtho[2,3-b]furan-4,9-dione derivatives from readily available precursors such as 2-hydroxy-1,4-naphthoquinone and nitroalkenes under aqueous conditions is described. Interesting features of this methodology are the conversion of a nitro functionality into an amino functionality in the absence of a reducing agent and the development of a three component reaction for accessing the same product from an aldehyde, 2-hydroxy-1,4-naphthoquinone and nitromethane.

引用

页码：8288 / 8298

页数：11

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