Combination of adoptive cell transfer, anti-PD-L1 and anti-LAG-3 antibodies for the treatment of recurrent tumors Better with more

被引：4

作者：

Goding, Stephen R. ^{[1
]}

Wilson, Kyle A. ^{[2
]}

Antony, Paul Andrew ^{[1
,2
,3
]}

机构：

[1] Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

[3] Univ Maryland, Ctr Canc, Tumor Immunol & Immunotherapy Program, Baltimore, MD 21201 USA

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 08期

关键词：

CD4 T cells; T regulatory cells; cancer recurrence; PD-L1; LAG-3; melanoma; Foxp3; PD-1; TIGIT; TIM3; CD4(+) T-CELLS; MELANOMA;

D O I：

10.4161/onci.25050

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor recurrence may result from the exhaustion of tumor-associated antigen (TAA)-specific T cells, which often occurs upon chronic antigen stimulation. we have recently shown that the blockade of the T-cell inhibitory receptors PD-L1 and LAG-3 restores TAA-speciic CD4(+) T-cell functions in mice bearing recurrent neoplasms, resulting in robust antineoplastic effects.

引用

页数：3

共 9 条

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