Antioxidant activity of secondary metabolites and mycelium extracts of endophytic fungi isolated from Astragalus monadelphus

被引：0

作者：

Wang, Y. G. ^{[1
]}

Yang, G. R. ^{[1
]}

Wang, F. ^{[2
]}

Yang, M. J. ^{[1
]}

Li, J. ^{[1
]}

Liu, X. F. ^{[1
]}

Wang, M. G. ^{[1
]}

Wang, X. L. ^{[3
]}

机构：

[1] Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China

[2] Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China

[3] CAAS, Lanzhou Inst Husb & Pharmaceut Sci, Lanzhou 730050, Peoples R China

来源：

BULGARIAN CHEMICAL COMMUNICATIONS | 2016年 / 48卷 / 04期

关键词：

Endophytic fungi; Secondary metabolites; Antioxidant activity; BETA-SITOSTEROL; YEW;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

13 strains of endophytic fungi were isolated from Astragalus monadelphus. The radical scavenging activity assay of secondary metabolites and mycelium extracts from these strains were investigated. Results showed that secondary metabolites and mycelium extracts from these strains had significant antioxidant activities. Reducing ability of H401 strain mycelium extracts were stronger than the ethyl acetate extract parts, and its EC50 value was 0.0034 mg/mL. Ethyl acetate parts of H802 strain exhibited strong center dot OH scavenging effect, the IC50 value was 0.0384 mg/mL. the DPPH radical scavenging activity test indicated that endophytic fungi can be a good source of radical scavenger. Besides, the compounds extracted from H401 secondary metabolites belong to beta-sitosterol based on the results of NMR analysis and literature data.

引用

页码：787 / 792

页数：6

共 16 条

[1] Poly(anhydride-esters) Comprised Exclusively of Naturally Occurring Antimicrobials and EDTA: Antioxidant and Antibacterial Activities [J].

Carbone-Howell, Ashley L. ;

Stebbins, Nicholas D. ;

Uhrich, Kathryn E. .

BIOMACROMOLECULES, 2014, 15 (05) :1889-1895

[2]

Gupta M. B., 1980, PLANTA MED, V39, P157

[3]

Ivanova M, 2014, J BALK TRIBOL ASSOC, V20, P665

[4]

Kimura T., 1998, J JPN SOC FOOD SCI, V45, P144

[5]

Koo K. J., 2014, J FOOD SCI, V4, P719

[6] SUBGLUTINOL-A AND SUBGLUTINOL-B - IMMUNOSUPPRESSIVE COMPOUNDS FROM THE ENDOPHYTIC FUNGUS FUSARIUM-SUBGLUTINANS [J].

LEE, JC ;

LOBKOVSKY, E ;

PLIAM, NB ;

STROBEL, G ;

CLARDY, J .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (22) :7076-7077

[7] Immunoregulatory activity by daucosterol, a β-sitosterol glycoside, induces protective Th1 immune response against disseminated Candidiasis in mice [J].

Lee, Jue-Hee ;

Lee, Ju Young ;

Park, Ji Hye ;

Jung, Hye Sil ;

Kim, Ju Sun ;

Kang, Sam Sik ;

Kim, Yeong Shik ;

Han, Yongmoon .

VACCINE, 2007, 25 (19) :3834-3840

[8] Purification of four strains of endophytic fungi from Astragalus and their optimized liquid fermentations [J].

Ma, Wei ;

Liu, Xiubo ;

Jiao, Jiao ;

Zhang, Leiming ;

Ren, Weichao ;

Ma, Ling ;

Kong, Xiangjun ;

Zhang, Ning ;

Zhang, Xiwu .

JOURNAL OF FORESTRY RESEARCH, 2014, 25 (03) :701-706

[9] Antioxidant activity index (AAI) by the 2,2-diphenyl-1-picrylhydrazyl method [J].

Scherer, Rodrigo ;

Godoy, Helena Teixeira .

FOOD CHEMISTRY, 2009, 112 (03) :654-658

[10]

Sheytanov I, 2013, J BALK TRIBOL ASSOC, V19, P265

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