An assessment of oxidant/antioxidant status and oxidative stress index levels in patients with carbon monoxide poisoning

Objective: The purposes of this study is to evaluate the variations of total antioxidant status (TAS) and total oxidant status (TOS) levels in the treatment process of carbon monoxide poisoning (COP) and to learn more about the pathophysiology of COP. Methods: Between 2011 and 2012, 113 patients were admitted to our emergency department with acute COP, and 50 healthy volunteers were used as a control group in this study. Serum, plasma and erythrocyte components were prepared for all the COP patients on admission. They were repeated at the 90th and 180th minute of treatment. The samples were taken once from the control group. Serum oxidant/antioxidant status levels and carboxyhaemoglobin (COHb) were measured. Ratio of TOS to TAS, known as oxidative stress index (OSI) was calculated. Results: No correlation was observed among age, gender, COHb level, with the levels of TAS, TOS, and OSI. Admission levels of TOS and OSI in patients with COP were higher than that observed at 90th minutes (p<0.001). These values were also higher in COP patients compared to control group (p<0.001). On the other hand, no statistical differences were observed in TAS levels between the study and control groups (p>0.05). Conclusions: Our results show that serum TOS and OSI levels increase in COP patients. Oxidative stress should play a role in the pathophysiology of COP.