Morphine tolerance in male and female rats

被引：31

作者：

Holtman, JR ^{[1
]}

Sloan, JW ^{[1
]}

Wala, EP ^{[1
]}

机构：

[1] Univ Kentucky, Coll Med, Chandler Med Ctr, Dept Anesthesiol, Lexington, KY 40536 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2004年 / 77卷 / 03期

关键词：

morphine tolerance; analgesia; locomotion; sex differences;

D O I：

10.1016/j.pbb.2003.12.020

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Several studies indicate greater sensitivity to morphine (MOR) analgesia in male compared to female rats under the acute dosing condition. The present study investigated whether the same sex difference in, sensitivity persists in MOR-tolerant rats. MOR was administered chronically (7 mg/kg twice daily) until tolerance developed in each rat. Tolerant rats were treated randomly with higher graded doses of MOR (10-25 mg/kg). Analgesia (tail-flick test) and spontaneous motor activity (total locomotion) were measured. The present data confirmed previous studies showing a greater sensitivity to acute MOR in male than in female rats. However, the sex differences seen in MOR sensitivity were abolished in tolerant rats. The rate of acquisition of tolerance was similar in male and female rats. The analgesic response was not affected by motor depression. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：517 / 523

页数：7

共 37 条

[1] Importance of sex and relative efficacy at the μ opioid receptor in the development of tolerance and cross-tolerance to the antinociceptive effects of opioids [J].

Barrett, AC ;

Cook, CD ;

Terner, JM ;

Craft, RM ;

Picker, MJ .

PSYCHOPHARMACOLOGY, 2001, 158 (02) :154-164

[2]

Bartok RE, 1997, J PHARMACOL EXP THER, V282, P769

[3]

BERGLUND LA, 1988, NEUROENDOCRINOLOGY, V48, P394, DOI 10.1159/000125040

[4] Microinjection of morphine into the rostral ventromedial medulla produces greater antinociception in male compared to female rats [J].

Boyer, JS ;

Morgan, MM ;

Craft, RM .

BRAIN RESEARCH, 1998, 796 (1-2) :315-318

[5] Gender differences in the intravenous self-administration of mu opiate agonists [J].

Cicero, TJ ;

Aylward, SC ;

Meyer, ER .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2003, 74 (03) :541-549

[6] Role of steroids in sex differences in morphine-induced analgesia: Activational and organizational effects [J].

Cicero, TJ ;

Nock, B ;

O'Connor, L ;

Meyer, ER .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 300 (02) :695-701

[7] Gender-linked differences in the expression of physical dependence in the rat [J].

Cicero, TJ ;

Nock, B ;

Meyer, ER .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2002, 72 (03) :691-697

[8] Gender differences in the reinforcing properties of morphine [J].

Cicero, TJ ;

Ennis, T ;

Ogden, J ;

Meyer, ER .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2000, 65 (01) :91-96

[9]

Cicero TJ, 1996, J PHARMACOL EXP THER, V279, P767

[10] Sex differences in opioid analgesia: "From mouse to man" [J].

Craft, RM .

CLINICAL JOURNAL OF PAIN, 2003, 19 (03) :175-186

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