Synthesis and evaluation of a novel rhodamine B-based 'off-on' fluorescent chemosensor for the selective determination of Fe3+ ions

被引：42

作者：

Chen, Hailang ^{[1
,3
]}

Bao, Xiaofeng ^{[1
]}

Shu, Hai ^{[1
]}

Zhou, Baojing ^{[3
]}

Ye, Renlong ^{[3
]}

Zhu, Jing ^{[2
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Environm & Biol Engn, 200 Xiaolinwei, Nanjing 210094, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, Dept Pharm, 138 Xianlin Dadao, Nanjing 210023, Jiangsu, Peoples R China

[3] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2017年 / 242卷

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

Rhodamine derivatives; Chemosensor; Fe3+; Fluorescent probe; CHROMOGENIC DETECTION; OPTICAL CHEMOSENSOR; IRON HOMEOSTASIS; CHEMICAL SENSOR; AQUEOUS-MEDIA; PROBE; AL3+; CU2+; CONJUGATE; FE(III);

D O I：

10.1016/j.snb.2016.09.163

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new rhodamine B derivative, namely, N-1-(benzo[d]thiazol-2-yl)-N-4-(2'-(3',6'-bis (diethylamino)-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)ethyl)malea-mide (RDBSF), was designed, synthesized, and structurally characterized to develop a new chemosensor. UV-vis absorption and fluorescence spectroscopic studies show that RDBSF exhibits high sensitivity and selectivity toward Fe3+ in the presence of many other metal cations in a Tris-HCI solution (1 mM, pH = 7.4) containing 30% MeCN by forming a 1:1 complex with Fe3+. The binding association constant (K-a) of RDBSF for Fe3+ was estimated as 1.52 x 10(4) M-1 in the solution. The detection limit of Fe3+ by RDBSF was further determined as 11.6 nM. Intracellular imaging applications demonstrated that RDBSF can be used as a fluorescent probe for the detection of Fe3+ in HepG-2 cells. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：921 / 931

页数：11

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