Ulcerative colitis and colorectal cancer: a follow-up study in Fukuoka, Japan

Background Our goal was to study the higher death rare and the causes of such deaths among ulcerative colitis (UC) patients in the Japanese population, and to compare our findings in such cases with those for Crohn's disease (CD). Methods In all, 174 UC (male/female: 54/120) and 66 CD (34/32) patients who were registered for the research promotion programme in Fukuoka prefecture (1971-1981) were traced up to the end of 1994. The standardized mortality ratios (SMR) were calculated based on the death rates of the Japanese population by age, sex and calendar year. Results The overall follow-up rate was 96.7%. Among the UC patients, the SMR for all causes were 0.84 (95% CI : 0.11-4.31) for men; 1.05 (95% CI : 0.08-4.69) for women; and 0.94 (95% CI : 9.09-4.50) for both sexes combined. When excluding deaths due to colorectal cancer, the SMR for the same groups were 0.43, 0.94 and 0.67, respectively. The SMR for both sexes were 1.82 (95% CI : 0.17-5.96) for malignant neoplasms and 9.93 (95% CI : 4.67-17.3) for colorectal cancer. Patients who died from colorectal cancer showed onset at a younger age (mean: 25.5 years) as well as a longer disease course of UC (mean: 17.0 years). Regarding the CD patients, the SMR for all causes were 1.75 (95% CI : 0.15-5.75) for both sexes. Most deaths were caused by gastrointestinal complications. Conclusions An excess mortality from colorectal cancers was indicated in the UC patients, especially in males. The overall SMR in male UC patients decreased by 50% when the deaths from colorectal cancer were excluded. The excess mortality in those with CD over UC patients was attributed to gastrointestinal complications rather than malignant diseases. Some carcinogenic factors therefore seem most likely to exist in the pathogenesis of UC.