Demystifying suberin

Suberin is a term used to define a specific cell wall component that occurs, for example, in phellem (cork) endodermal and exodermal cells and is characterized by the deposition of both poly(phenolic) and poly(aliphatic) domains. Historically, the poly(phenolic) domain has been likened to lignin, and while there is an element of truth to this comparison, recent evidence supports an alternative view in which the poly(phenolic) domain contains a significant amount of nonlignin precursors (principally hydroxycinnamic acids and their derivatives) that are covalently linked to each other in a manner analogous to the monolignols in lignin. Similarly, the conceptual model in which the poly(aliphatic) domain of suberized tissues is represented as a random network of polyesterified, modified fatty acids and alcohols has been replaced with one comprising a three-dimensional, glycerol-bridged network. Taken together, a new model for suberin is emerging in which a hydroxycinnamic acid - monolignol poly(phenolic) domain, embedded in the primary cell wall, is covalently linked to a glycerol-based poly(aliphatic) domain located between the primary cell wall and the plasma membrane. The structural and biochemical evidence supporting this new suberin paradigm are examined in this minireview, along with the presentation of a new structural model encompassing a current view of the structure of suberin.