Lamotrigine in the treatment of nocturnal myoclonus syndrome (NMS): Two case reports

被引：13

作者：

Staedt, J ^{[1
]}

Stoppe, G ^{[1
]}

Riemann, H ^{[1
]}

Hajak, G ^{[1
]}

Ruther, E ^{[1
]}

Riederer, P ^{[1
]}

机构：

[1] UNIV WURZBURG,DEPT PSYCHIAT,D-8700 WURZBURG,GERMANY

来源：

JOURNAL OF NEURAL TRANSMISSION | 1996年 / 103卷 / 03期

关键词：

nocturnal myoclonus syndrome; NMS; lamotrigine; dopamine; glutamate;

D O I：

10.1007/BF01271247

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In previous investigations we found an increase of D2 dopamine receptors in the striatum of patients with nocturnal myoclonus syndrome (NMS) after treatment with dopamimetics. Under the hypothesis, that, according to animal experiments, the glutamatergic system could be involved in this atypical dopaminergic up-regulation in NMS. The glutamate release inhibitor lamotrigine was tested in up to now two NMS patients. The results and the success of this approach and its implications are discussed.

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收藏

页码：355 / 361

页数：7

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