Evaluation of the central activity of hydroxydihydrocarvone

被引:41
作者
de Sousa, DP [1 ]
Oliveira, FD [1 ]
de Almeida, RN [1 ]
机构
[1] Univ Fed Paraiba, Lab Tecnol Farmaceut, BR-58051970 Pessoa, Paraiba, Brazil
关键词
hydroxydihydrocarvone; essential oil; monoterpene; antinociceptive activity; anticonvulsant activity; carvone;
D O I
10.1248/bpb.29.811
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The central effects of hydroxydihydrocarvone (HC)an analogue of several monoterpenes, were evaluated in animal models. General behavior, locomotor activity, pentobarbital-induced sleeping time, pentylenetetrazol (PTZ)-induced convulsions, and acetic acid-induced writhing were evaluated in mice. The compound caused palpebral ptosis, decreased the response to touch, and increased sedation (general behavioral profile). HC (50-200 mg/kg) caused a significant dose-dependent decrease in the spontaneous motor activity of mice. This compound (100, 200 mg/kg) potentiated the pentobarbital sleeping time, indicating a depressant action. HC also protected the mice against PTZ-induced convulsions at 400 mg/kg. In the acetic acid-induced writhing, the antinociceptive activity of HC was demonstrated with a significant dose-dependent response at a dose range of 25-400 mg/kg. The present results provide evidence that HC has significant psychopharmacologic activity with depressant effects.
引用
收藏
页码:811 / 812
页数:2
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