Rh(III)-Catalyzed [3+2] Spirocyclization of 2H-Imidazoles with 1,3-Diynes for the Synthesis of Spiro-[imidazole-indene] Derivatives

被引：29

作者：

Luo, Yi ^{[1
]}

Liu, Hao ^{[1
]}

Zhang, Jing ^{[1
]}

Liu, Man ^{[1
]}

Dong, Lin ^{[1
]}

机构：

[1] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, Key Lab Drug Targeting & Drug Delivery Syst, West China Sch Pharm,Educ Minist, Chengdu 610041, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 19期

关键词：

CARDIOTONIC AGENTS; ANNULATION; KETIMINES; ACTIVATION;

D O I：

10.1021/acs.orglett.0c02805

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An effective strategy to synthesize spirocyclic compounds, [imidazole-4,1'-indene], has been efficaciously developed relied on Rh(III)-catalyzed [3 + 2] spirocyclization of 2H-imidazoles and 1,3-diynes with excellent chemselectivity and regioselectivity. This protocol shows a straightforward way to construct the versatile spirocyclic compounds with wide functional group compatibility, high atom economy, and diverse functionalization of products.

引用

页码：7604 / 7608

页数：5

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