Rh(III)-Catalyzed [3+2] Spirocyclization of 2H-Imidazoles with 1,3-Diynes for the Synthesis of Spiro-[imidazole-indene] Derivatives

被引：29
作者：
Luo, Yi [1 ]
Liu, Hao [1 ]
Zhang, Jing [1 ]
Liu, Man [1 ]
Dong, Lin [1 ]
机构：
[1] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, Key Lab Drug Targeting & Drug Delivery Syst, West China Sch Pharm,Educ Minist, Chengdu 610041, Peoples R China
来源：
ORGANIC LETTERS | 2020年 / 22卷 / 19期
关键词：
CARDIOTONIC AGENTS; ANNULATION; KETIMINES; ACTIVATION;
D O I：
10.1021/acs.orglett.0c02805
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An effective strategy to synthesize spirocyclic compounds, [imidazole-4,1'-indene], has been efficaciously developed relied on Rh(III)-catalyzed [3 + 2] spirocyclization of 2H-imidazoles and 1,3-diynes with excellent chemselectivity and regioselectivity. This protocol shows a straightforward way to construct the versatile spirocyclic compounds with wide functional group compatibility, high atom economy, and diverse functionalization of products.
引用
收藏
页码：7604 / 7608
页数：5
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