Microwave-Assisted Solid Phase Synthesis of GLP-1-Analogues

被引：11

作者：

Chi, Yushi ^{[1
]}

Zhang, Huibin ^{[1
]}

Zhou, Jinpei ^{[1
]}

Huang, Wenlong ^{[1
]}

Ni, Shuaijian ^{[1
]}

机构：

[1] China Pharmaceut Univ, Ctr Drug Res, Nanjing 210009, Peoples R China

来源：

LETTERS IN ORGANIC CHEMISTRY | 2008年 / 5卷 / 05期

关键词：

Microwave; GLP-1; solid phase; peptide;

D O I：

10.2174/157017808784872061

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Gly8-GLP-1 (7 similar to 36) amide and Exendin-4, analogues of Glucagon-like peptide-1 (GLP-1), were synthesized rapidly and efficiently on rink amide MBHA resin under microwave irradiation, using Fmoc/tBu orthogonal protection strategy. The results showed that the synthesis of the medium-to large-length peptides was greatly improved in the reaction time and the purity of crude product with the use of microwave irradiation.

引用

页码：399 / 402

页数：4

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