An Intraoperative Model for Predicting Survival and Deciding Therapeutic Schedules: A Comprehensive Analysis of Peritoneal Metastasis in Patients With Advanced Gastric Cancer

被引：5

作者：

Chen, Qi-Yue ^{[1
,2
]}

Liu, Zhi-Yu ^{[1
,2
]}

Zhong, Qing ^{[1
,2
]}

Jiang, Wen ^{[3
,4
]}

Zhao, Ya-Jun ^{[3
,4
]}

Li, Ping ^{[1
,2
,5
]}

Wang, Jia-Bin ^{[1
,2
,5
]}

Lin, Jian-Xian ^{[1
,2
,5
]}

Lu, Jun ^{[1
,2
,5
]}

Cao, Long-Long ^{[1
,2
]}

Lin, Mi ^{[1
,2
]}

Tu, Ru-Hong ^{[1
,2
]}

Huang, Ze-Ning ^{[1
,2
]}

Lin, Ju-Li ^{[1
,2
]}

Zheng, Hua-Long ^{[1
,2
]}

Que, Si-Jin ^{[1
,2
]}

Zheng, Chao-Hui ^{[1
,2
,5
]}

Huang, Chang-Ming ^{[1
,2
,5
]}

Xie, Jian-Wei ^{[1
,2
]}

机构：

[1] Fujian Med Univ, Dept Gastr Surg, Union Hosp, Fuzhou, Peoples R China

[2] Fujian Med Univ, Dept Gen Surg, Union Hosp, Fuzhou, Peoples R China

[3] Univ Sci & Technol China, Affiliated Hosp 1, Dept Gastrointestinal Surg, Div Life Sci & Med, Hefei, Peoples R China

[4] Anhui Med Univ, Anhui Prov Hosp, Hefei, Peoples R China

[5] Fujian Med Univ, Minist Educ Gastrointestinal Canc, Key Lab, Fuzhou, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2020年 / 10卷

关键词：

gastric cancer; peritoneal metastasis; preoperative blood index; prognosis model; therapy; PROGNOSTIC MODEL; CHEMOTHERAPY; GASTRECTOMY; INFLAMMATION; CARCINOMA; RESECTION; NOMOGRAM;

D O I：

10.3389/fonc.2020.550526

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and Objective:No specialized prognostic model for patients with gastric cancer with peritoneal metastasis (GCPM) exists for intraoperative clinical decision making. This study aims to establish a new prognostic model to provide individual treatment decisions for patients with GCPM. Method:This retrospective analysis included 324 patients with GCPM diagnosed pathologically by laparoscopy from January 2007 to January 2018 who were randomly assigned to different sets (227 in the training set and 97 in the internal validation set). A nomogram was established from preoperative and intraoperative variables determined by a Cox model. The predictive ability and clinical applicability of the PM nomogram (PMN) were compared with the 15th Japanese Classification of Gastric Carcinoma (JCGC) Staging Guidelines for PM (P1abc). Additional external validation was performed using a dataset (n= 39) from the First Affiliated Hospital of University of Science and Technology of China. Results:The median survival time was 8 (range, 1-90) months. In the training set, each PMN substage had significantly different survival curves (P< 0.001), and the PMN was superior to the P1abc based on the results of time-dependent receiver operating characteristic curve, C-index, Akaike information criterion and likelihood ratio chi-square analyses. In the internal and external validation sets, the PMN was also better than the P1abc in terms of its predictive ability. Of the PMN1 patients, those undergoing palliative resection had better overall survival (OS) than those undergoing exploratory surgery (P< 0.05). Among the patients undergoing exploratory surgery, those who received chemotherapy exhibited better OS than those who did not (P< 0.05). Among the patients who received palliative resection, only PMN1 patients exhibited better OS following chemotherapy (P< 0.05). Conclusion:We developed and validated a simple, specific PM model for patients with GCPM that can predict prognosis well and guide treatment decisions.

引用

页数：12