Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes

被引:82
作者
de la Serrana, Daniel Garcia [1 ]
Macqueen, Daniel J. [2 ]
机构
[1] Univ St Andrews, Scottish Oceans Inst, Sch Biol, St Andrews, Fife, Scotland
[2] Univ Aberdeen, Sch Biol Sci, Aberdeen, Scotland
关键词
insulin-like growth factor binding protein; teleost fish; genome duplication; physiology; comparative biology; gene family evolution; TROUT ONCORHYNCHUS-MYKISS; IGF-BINDING; ATLANTIC SALMON; RAINBOW-TROUT; HORMONAL-REGULATION; FACTOR-I; TRANSCRIPTIONAL REGULATION; PHYSIOLOGICAL REGULATION; OREOCHROMIS-MOSSAMBICUS; ICTALURUS-PUNCTATUS;
D O I
10.3389/fendo.2018.00080
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The insulin-like growth factor (Igf) binding protein (Igfbp) family has a broad range of physiological functions and a fascinating evolutionary history. This review focuses on the Igfbps of teleost fishes, where genome duplication events have diversified gene repertoire, function, and physiological regulation with six core Igfbps expanded into a family of over twenty genes in some lineages. In addition to briefly summarizing the current state of knowledge on teleost Igfbp evolution, function, and expression-level regulation, we highlight gaps in our understanding and promising areas for future work.
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页数:12
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