RHEUMATOID ARTHRITIS Obesity impairs efficacy of anti-TNF therapy in patients with RA

被引：18

作者：

Gonzalez-Gay, Miguel A. ^{[1
]}

Gonzalez-Juanatey, Carlos ^{[2
]}

机构：

[1] Hosp Univ Marques de Valdecilla, IFIMAV, Div Rheumatol, Santander 39008, Spain

[2] Hosp Univ Lucus Augusti, Div Cardiol, Lugo 27003, Spain

来源：

NATURE REVIEWS RHEUMATOLOGY | 2012年 / 8卷 / 11期

关键词：

INSULIN-RESISTANCE; SENSITIVITY;

D O I：

10.1038/nrrheum.2012.158

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin resistance is closely associated with an increased risk of subclinical atherosclerosis in patients with rheumatoid arthritis (RA). Anti-TNF therapy reduces insulin resistance and improves insulin sensitivity in patients with severe RA. New findings have shown, however, that the efficacy of these agents in this regard is impaired by obesity. Gonzalez-Gay, M. A. & Gonzalez-Juanatey, C. Nat. Rev. Rheumatol. 8, 641-642 (2012); published online 25 September 2012; doi:10.1038/nrrheum.2012.158

引用

页码：641 / 642

页数：3

共 10 条

[1] Inflammation-associated insulin resistance - Differential effects in rheumatoid arthritis and systemic lupus erythematosus define potential mechanisms [J].

Chung, Cecilia P. ;

Oeser, Annette ;

Solus, Joseph F. ;

Gebretsadik, Tebeb ;

Shintani, Ayumi ;

Avalos, Ingrid ;

Sokka, Tuulikki ;

Raggi, Paolo ;

Pincus, Theodore ;

Stein, C. Michael .

ARTHRITIS AND RHEUMATISM, 2008, 58 (07) :2105-2112

[2] Abdominal obesity and metabolic syndrome [J].

Despres, Jean-Pierre ;

Lemieux, Isabelle .

NATURE, 2006, 444 (7121) :881-887

[3]

Dessein PH, 2006, J RHEUMATOL, V33, P2425

[4] Rheumatoid arthritis: A disease associated with accelerated atherogenesis [J].

Gonzalez-Gay, MA ;

Gonzalez-Juanatey, C ;

Martin, J .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2005, 35 (01) :8-17

[5]

Gonzalez-Gay MA, 2006, CLIN EXP RHEUMATOL, V24, P83

[6] Insulin resistance in rheumatoid arthritis: the impact of the anti-TNF-α therapy [J].

Gonzalez-Gay, Miguel A. ;

Gonzalez-Juanatey, Carlos ;

Vazquez-Rodriguez, Tomas R. ;

Miranda-Filloy, Jose A. ;

Llorca, Javier .

NEUROENDOCRINE IMMUNOLOGY IN RHEUMATIC DISEASES: TRANSLATION FROM BASICS TO CLINICS, 2010, 1193 :153-159

[7] Improved insulin sensitivity by anti-TNFα antibody treatment in patients with rheumatic diseases [J].

Huvers, Frank C. ;

Popa, Calin ;

Netea, Mihai G. ;

van den Hoogen, Frank H. J. ;

Tack, Cees J. .

ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (04) :558-559

[8] Insulin resistance: definition and consequences [J].

Lebovitz, HE .

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2001, 109 :S135-S148

[9]

MIRANDA-FILLOY JA, CLIN EXP RH IN PRESS

[10] Anti-tumour necrosis factor alpha therapy improves insulin sensitivity in normal-weight but not in obese patients with rheumatoid arthritis [J].

Stavropoulos-Kalinoglou, Antonios ;

Metsios, Giorgos S. ;

Panoulas, Vasileios F. ;

Nightingale, Peter ;

Koutedakis, Yiannis ;

Kitas, George D. .

ARTHRITIS RESEARCH & THERAPY, 2012, 14 (04)

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