The plasticity and stability of regulatory T cells

被引：412
作者：
Sakaguchi, Shimon [1 ,2 ]
Vignali, Dario A. A. [3 ]
Rudensky, Alexander Y. [4 ,5 ]
Niec, Rachel E. [4 ,5 ]
Waldmann, Herman [6 ]
机构：
[1] Osaka Univ, World Premier Int Immunol Frontier Res Ctr, Suita, Osaka 5650871, Japan
[2] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Kyoto 6068507, Japan
[3] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
[4] Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA
[5] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10065 USA
[6] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
来源：
NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 06期
基金：
美国国家卫生研究院;
关键词：
FOXP3; EXPRESSION; HISTONE DEACETYLASES; SUPPRESSION; TOLERANCE; INSTABILITY; MECHANISMS; GENE;
D O I：
10.1038/nri3464
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Regulatory T (T-Reg) cells are crucial for the prevention of fatal autoimmunity in mice and humans. Forkhead box P3 (FOXP3)(+) T-Reg cells are produced in the thymus and are also generated from conventional CD4(+) T cells in peripheral sites. It has been suggested that FOXP3(+) T-Reg cells might become unstable under certain inflammatory conditions and might adopt a phenotype that is more characteristic of effector CD4(+) T cells. These suggestions have caused considerable debate in the field and have important implications for the therapeutic use of T-Reg cells. In this article, Nature Reviews Immunology asks several experts for their views on the plasticity and stability of T-Reg cells.
引用
收藏
页码：461 / 467
页数：7
相关论文
共 48 条
[11]   Epigenetic control of the foxp3 locus in regulatory T cells [J].
Floess, Stefan ;
Freyer, Jennifer ;
Siewert, Christiane ;
Baron, Udo ;
Olek, Sven ;
Polansky, Julia ;
Schlawe, Kerstin ;
Chang, Hyun-Dong ;
Bopp, Tobias ;
Schmitt, Edgar ;
Klein-Hessling, Stefan ;
Serfling, Edgar ;
Hamann, Alf ;
Huehn, Jochen .
PLOS BIOLOGY, 2007, 5 (02) :169-178
[12]   Regulatory T cell lineage specification by the forkhead transcription factor FoxP3 [J].
Fontenot, JD ;
Rasmussen, JP ;
Williams, LM ;
Dooley, JL ;
Farr, AG ;
Rudensky, AY .
IMMUNITY, 2005, 22 (03) :329-341
[13]   A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells [J].
Fu, Wenxian ;
Ergun, Ayla ;
Lu, Ting ;
Hill, Jonathan A. ;
Haxhinasto, Sokol ;
Fassett, Marlys S. ;
Gazit, Roi ;
Adoro, Stanley ;
Glimcher, Laurie ;
Chan, Susan ;
Kastner, Philippe ;
Rossi, Derrick ;
Collins, James J. ;
Mathis, Diane ;
Benoist, Christophe .
NATURE IMMUNOLOGY, 2012, 13 (10) :972-980
[14]   Control of regulatory T cell development by the transcription factor Foxp3 [J].
Hori, S ;
Nomura, T ;
Sakaguchi, S .
SCIENCE, 2003, 299 (5609) :1057-1061
[15]   Stability of Regulatory T-cell Lineage [J].
Hori, Shohei .
ADVANCES IN IMMUNOLOGY: REGULATORY T-CELLS, VOL 112, 2011, 112 :1-24
[16]   Regulatory T Cells: Mechanisms of Differentiation and Function [J].
Josefowicz, Steven Z. ;
Lu, Li-Fan ;
Rudensky, Alexander Y. .
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30, 2012, 30 :531-564
[17]   Extrathymically generated regulatory T cells control mucosal TH2 inflammation [J].
Josefowicz, Steven Z. ;
Niec, Rachel E. ;
Kim, Hye Young ;
Treuting, Piper ;
Chinen, Takatoshi ;
Zheng, Ye ;
Umetsu, Dale T. ;
Rudensky, Alexander Y. .
NATURE, 2012, 482 (7385) :395-U1510
[18]   Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance [J].
Kendal, Adrian R. ;
Chen, Ye ;
Regateiro, Frederico S. ;
Ma, Jianbo ;
Adams, Elizabeth ;
Cobbold, Stephen P. ;
Hori, Shohei ;
Waldmann, Herman .
JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (10) :2043-2053
[19]   The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation [J].
Koch, Meghan A. ;
Tucker-Heard, Glady's ;
Perdue, Nikole R. ;
Killebrew, Justin R. ;
Urdahl, Kevin B. ;
Campbell, Daniel J. .
NATURE IMMUNOLOGY, 2009, 10 (06) :595-U57
[20]   Distinct Inflammatory Signals Have Physiologically Divergent Effects on Epigenetic Regulation of Foxp3 Expression and Treg Function [J].
Lal, G. ;
Yin, N. ;
Xu, J. ;
Lin, M. ;
Schroppel, S. ;
Ding, Y. ;
Marie, I. ;
Levy, D. E. ;
Bromberg, J. S. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2011, 11 (02) :203-214
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