The plasticity and stability of regulatory T cells

被引：412

作者：

Sakaguchi, Shimon ^{[1
,2
]}

Vignali, Dario A. A. ^{[3
]}

Rudensky, Alexander Y. ^{[4
,5
]}

Niec, Rachel E. ^{[4
,5
]}

Waldmann, Herman ^{[6
]}

机构：

[1] Osaka Univ, World Premier Int Immunol Frontier Res Ctr, Suita, Osaka 5650871, Japan

[2] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Kyoto 6068507, Japan

[3] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

[4] Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA

[5] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10065 USA

[6] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 06期

基金：

美国国家卫生研究院;

关键词：

FOXP3; EXPRESSION; HISTONE DEACETYLASES; SUPPRESSION; TOLERANCE; INSTABILITY; MECHANISMS; GENE;

D O I：

10.1038/nri3464

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T (T-Reg) cells are crucial for the prevention of fatal autoimmunity in mice and humans. Forkhead box P3 (FOXP3)(+) T-Reg cells are produced in the thymus and are also generated from conventional CD4(+) T cells in peripheral sites. It has been suggested that FOXP3(+) T-Reg cells might become unstable under certain inflammatory conditions and might adopt a phenotype that is more characteristic of effector CD4(+) T cells. These suggestions have caused considerable debate in the field and have important implications for the therapeutic use of T-Reg cells. In this article, Nature Reviews Immunology asks several experts for their views on the plasticity and stability of T-Reg cells.

引用

页码：461 / 467

页数：7

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