Immunization with an adjuvant hepatitis B vaccine in liver transplant recipients:: Antibody decline and booster vaccination with conventional vaccine

被引:31
作者
Günther, M
Neuhaus, R
Bauer, T
Jilg, W
Holtz, JA
Bienzle, U
机构
[1] Humboldt Univ, Charite, Inst Trop Med, D-14050 Berlin, Germany
[2] Humboldt Univ, Charite, Dept Gen Visceral & Transplantat Surg, Berlin, Germany
[3] Univ Regensburg, Inst Med Microbiol & Hyg, Regensburg, Germany
关键词
D O I
10.1002/lt.20674
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Patients after orthotopic liver transplantation (OLT) due to hepatitis B virus (HBV)-related disease are at risk of endogenous hepatitis B reinfection and may receive life long prophylaxis with hepatitis B hyperimmunoglobulin (HBIG). In a previous study 16 of 20 OLT patients were immunized successfully with an adjuvant hepatitis B vaccine. To maintain protective antibody levels under immunosuppressive therapy, 11 of these patients were revaccinated with a double dosed conventional hepatitis B vaccine. Median interval between last vaccination and booster was 24 months (range 22-31 months). Antibody titres against hepatitis B surface antigen (anti-HBs) were monitored at the day of booster vaccination (day 0), at day 7 and day 28. At day 0, all vaccinees but one had anti-HBs titres greater than 500 IU/L (median 1,925 IU/L, range 196-7,612 IU/L). Maximum antibody titres after previous vaccination declined by a median of 82% (range 47-96%). After booster vaccination the anti-HBs titre increased significantly by a median factor of 2.42 (P < 0.05). In conclusion, the majority of liver transplant recipients who previously had responded to adjuvant hepatitis B vaccine exhibited sufficient immunocompetence to produce a substantial antibody response after booster immunization with a conventional vaccine.
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页码:316 / 319
页数:4
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