Immunotherapies for malignant glioma

被引：101
作者：
Boussiotis, Vassiliki A. [1 ,2 ,3 ]
Charest, Alain [2 ,3 ,4 ]
机构：
[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Hematol Oncol, Boston, MA USA
[2] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02115 USA
[3] Harvard Med Sch, Beth Israel Deaconess Canc Ctr, Boston, MA 02115 USA
[4] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Genet, Boston, MA 02115 USA
来源：
ONCOGENE | 2018年 / 37卷 / 09期
关键词：
CENTRAL-NERVOUS-SYSTEM; REGULATORY T-CELLS; CANCER STEM-CELLS; NEWLY-DIAGNOSED GLIOBLASTOMA; CHIMERIC ANTIGEN RECEPTOR; BLOOD-BRAIN-BARRIER; TUMOR-ASSOCIATED MACROPHAGES; IMMUNE CHECKPOINT BLOCKADE; GROWTH-FACTOR RECEPTOR; MICROGLIAL CELLS;
D O I：
10.1038/s41388-017-0024-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glioblastoma multiforme (GBM) is a highly malignant primary brain cancer with a dreadful overall survival and for which treatment options are limited. Recent breakthroughs in novel immune-related treatment strategies for cancer have spurred interests in usurping the power of the patient's immune system to recognize and eliminate GBM. Here, we discuss the unique properties of GBM's tumor microenvironment, the effects of GBM standard on care therapy on tumor-associated immune cells, and review several approaches aimed at therapeutically targeting the immune system for GBM treatment. We believe that a comprehensive understanding of the intricate micro-environmental landscape of GBM will abound into the development of novel immunotherapy strategies for GBM patients.
引用
收藏
页码：1121 / 1141
页数：21
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