Protective effect of cepharanthin on cisplatin-induced renal toxicity through metallothionein expression

被引：14

作者：

Sogawa, Norio ^{[1
]}

Hirai, Kanji ^{[1
]}

Sogawa, Chiharu ^{[1
]}

Ohyama, Kazumi ^{[2
]}

Miyazaki, Ikuko ^{[3
]}

Tsukamoto, Goichi ^{[4
]}

Asanuma, Masato ^{[3
]}

Sasaki, Akira ^{[4
]}

Kitayama, Shigeo ^{[1
]}

机构：

[1] Okayama Univ, Dept Dent Pharmacol, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008558, Japan

[2] Okayama Univ, Sch Dent, RI Res Ctr, Okayama 7008558, Japan

[3] Okayama Univ, Dept Brain Sci, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008558, Japan

[4] Okayama Univ, Dept Oral & Maxillofacial Surg & Biopathol, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008558, Japan

来源：

LIFE SCIENCES | 2013年 / 92卷 / 12期

关键词：

Cepharanthine; Herbal medicines; Cisplatin; Renal toxicity; Metallothionein; SQUAMOUS-CELL CARCINOMA; BISCOCLAURINE ALKALOID CEPHARANTHINE; EXERTS ANTITUMOR-ACTIVITY; NF-KAPPA-B; ANTICANCER DRUGS; NUDE-MICE; CANCER; NEPHROTOXICITY; INDUCTION; COMBINATION;

D O I：

10.1016/j.lfs.2013.01.031

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aims: Cisplatin (CDDP) is a potent anticancer agent, but severe renal toxicity can limit its use. We investigated the protective effect of cepharanthin (CE), a biscoclaurin alkaloid, on the renal toxicity of CDDP. Main methods: Mice were given CDDP along with CE. Effects of CE on CDDP toxicity were investigated by assaying markers of renal toxicity together with MT expression, and by histopathological examination of the kidney. MT-null mice were also examined. Key findings: CE induced expression of metallothionein (MT). Pre-administration of CE attenuated an increase in blood urea nitrogen (BUN) concentrations after the CDDP injection. A histochemical analysis demonstrated protection against CDDP-induced necrocytosis of kidney tissues by CE. The protective effect of CE did not occur in the MT-null mice. Significance: Pretreatment with CE may reduce the renal toxicity of CDDP through expression of MT. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：727 / 732

页数：6

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