A novel amino acid functionalized ionic liquid promoted one-pot solvent-free synthesis of 3,4-dihydropyrimidin-2-(1H)-thiones

被引：14

作者：

Karthikeyan, Parasuraman ^{[1
]}

Kumar, Sythana Suresh ^{[1
]}

Arunrao, Aswar Sachin ^{[1
]}

Narayan, Muskawar Prashant ^{[1
]}

Bhagat, Pundlik Rambhau ^{[1
]}

机构：

[1] VIT Univ, Sch Adv Sci, Div Organ Chem, Vellore 632014, Tamil Nadu, India

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2013年 / 39卷 / 03期

关键词：

Amino acid; Ionic liquid; Thiourea; Reflux; EFFICIENT SYNTHESIS; REUSABLE CATALYST; SILICA; PROTOCOL; WATER;

D O I：

10.1007/s11164-012-0689-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An environmentally benign, cheap and reusable L-amino acid functionalized ionic liquid [L-AAIL]/AlCl3 was found to be an effective catalyst for the synthesis of 3,4-dihydropyrimidine-2-(1H)-thione derivatives in good to excellent yield under solvent-free condition. Compared with the classical Biginelli reactions, this method consistently enjoys the advantages of mild reaction conditions, easy work-up, and short reaction time. These one-pot three-component Biginelli products could be separated easily from the catalyst-water system, and the catalyst could be reused at least five times without noticeably reducing catalytic activity.

引用

页码：1335 / 1342

页数：8

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