A novel amino acid functionalized ionic liquid promoted one-pot solvent-free synthesis of 3,4-dihydropyrimidin-2-(1H)-thiones

被引：14
|
作者：
Karthikeyan, Parasuraman [1 ]
Kumar, Sythana Suresh [1 ]
Arunrao, Aswar Sachin [1 ]
Narayan, Muskawar Prashant [1 ]
Bhagat, Pundlik Rambhau [1 ]
机构：
[1] VIT Univ, Sch Adv Sci, Div Organ Chem, Vellore 632014, Tamil Nadu, India
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2013年 / 39卷 / 03期
关键词：
Amino acid; Ionic liquid; Thiourea; Reflux; EFFICIENT SYNTHESIS; REUSABLE CATALYST; SILICA; PROTOCOL; WATER;
D O I：
10.1007/s11164-012-0689-4
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An environmentally benign, cheap and reusable L-amino acid functionalized ionic liquid [L-AAIL]/AlCl3 was found to be an effective catalyst for the synthesis of 3,4-dihydropyrimidine-2-(1H)-thione derivatives in good to excellent yield under solvent-free condition. Compared with the classical Biginelli reactions, this method consistently enjoys the advantages of mild reaction conditions, easy work-up, and short reaction time. These one-pot three-component Biginelli products could be separated easily from the catalyst-water system, and the catalyst could be reused at least five times without noticeably reducing catalytic activity.
引用
收藏
页码：1335 / 1342
页数：8
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