Palladium-Catalyzed Enantioselective C-H Aminocarbonylation: Synthesis of Chiral Isoquinolinones

被引：50

作者：

Han, Hui ^{[1
,2
]}

Zhang, Tao ^{[3
]}

Yang, Shang-Dong ^{[2
]}

Lan, Yu ^{[3
,5
]}

Xia, Ji-Bao ^{[1
,4
]}

机构：

[1] Univ Chinese Acad Sci, Chinese Acad Sci, Suzhou Res Inst LICP, LICP,State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China

[2] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China

[3] Chongqing Univ, Sch Chem & Chem Engn, Chongqing 400030, Peoples R China

[4] Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

[5] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 06期

关键词：

OXIDATIVE CARBONYLATION; ALIPHATIC-AMINES; C(SP(3))-H BONDS; ACTIVATION; LIGANDS; FUNCTIONALIZATION; FERROCENES; IODINATION; DERIVATIVES; ALKYLATION;

D O I：

10.1021/acs.orglett.9b00315

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd-catalyzed enantioselective C-H carbonylation by desymmetrization was developed with commercially available L-pyroglutamic acid as chiral ligand. Isoquinolinones were successfully obtained with good yields and high enantioselectivities. Mechanistic studies and DFT calculations provided a reasonable reaction pathway.

引用

页码：1749 / 1754

页数：6

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