Palladium-Catalyzed Dehydrogenation of Benzyl Alcohols for Construction of 2-Arylbenzimidazoles "On Water"

被引：27

作者：

Hikawa, Hidemasa ^{[1
]}

Ichinose, Risa ^{[1
]}

Kikkawa, Shoko ^{[1
]}

Azumaya, Isao ^{[1
]}

机构：

[1] Toho Univ, Fac Pharmaceut Sci, 2-2-1 Miyama, Funabashi, Chiba 2748510, Japan

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 7卷 / 02期

关键词：

benzimidazole; benzyl alcohol; dehydrogenation; on water; palladium; ONE-POT SYNTHESIS; C-H AMIDATION; ON-WATER; 1,2-DISUBSTITUTED BENZIMIDAZOLES; EFFICIENT SYNTHESIS; ORGANIC-SYNTHESIS; N BONDS; QUINOXALINES; ALKYLATION; BENZOTHIAZOLES;

D O I：

10.1002/ajoc.201700618

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An "on water" synthetic strategy for the selective construction of 2-arylbenzimidazoles involving the dehydrogenation of benzyl alcohols by a pi-benzylpalladium(II) system has been developed. This simple oxidant- and base-free protocol can be achieved under mild conditions in an atom-economic process from o-phenylenediamines and benzyl alcohols, affording the desired products in moderate to excellent yields. Notably, the "on water" protocol is essential for achieving this new synthetic method in our catalytic system.

引用

页码：416 / 423

页数：8

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