Allosteric modulation of the nicotinic acetylcholine receptor by physostigmine

被引：6
|
作者：
Svobodová, L
Krusek, J
Hendrych, T
Vyskocil, F
机构：
[1] Acad Sci Czech Republ, Inst Physiol, CR-14220 Prague, Czech Republic
[2] Charles Univ, Dept Anim Physiol & Dev Biol, Prague, Czech Republic
来源：
BIOPHYSICS FROM MOLECULES TO BRAIN: IN MEMORY OF RADOSLAV K. ANDJUS | 2005年 / 1048卷
关键词：
nicotinic ACh receptor; serine; desensitization; allosteric;
D O I：
10.1196/annals.1342.037
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The action of physostigmine on mouse muscle nicotinic acetylcholine receptor expressed in the COS-7 cell line was studied by the patch-clamp technique. Physostigmine accelerated, by allosteric modulation, the rate of desensitization of whole cell currents induced by acetylcholine and decreased the maximal amplitude in concentration-dependent manner.
引用
收藏
页码：355 / 358
页数：4
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