The Gadonanotubes revisited: A new frontier in MRI contrast agent design

被引：27
作者：
Sethi, Richa
Mackeyev, Yuri
Wilson, Lon J. [1 ]
机构：
[1] Rice Univ, Dept Chem, Houston, TX 77251 USA
来源：
INORGANICA CHIMICA ACTA | 2012年 / 393卷
关键词：
Magnetic resonance imaging; Single-walled carbon nanotubes; Gd-based contrast agents; Gadonanotubes; WALLED CARBON NANOTUBES; PHYSICOCHEMICAL PROPERTIES; WATER-EXCHANGE; GADOLINIUM; COMPLEXES; FUNCTIONALIZATION; NANOCAPSULES; LUMINESCENCE; STABILITIES; RELAXIVITY;
D O I：
10.1016/j.ica.2012.07.004
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In this review, the application of the Gadonanotubes (GNTs) as high-performance magnetic resonance imaging (MRI) contrast agents (CAs) is discussed. Through published and some unpublished work, we describe how the loading and nanoscale confinement of multiple Gd3+ ions within ultra-short single-walled carbon nanotubes (US-tubes) produces GNTs with MRI efficacies 40 to 90 times greater than current clinical CAs. Since there is a continuing need to increase MRI sensitivity, the molecular factors affecting the performance of Gd3+-based CAs are described and their optimization is considered for Gd3+-based agents, in general, and the GNTs in particular. The GNTs are new (ca. 2005) high-performance nanotechnology-inspired MRI CAs with promise for advanced T-1-weighted MR molecular imaging applications. Published by Elsevier B. V.
引用
收藏
页码：165 / 172
页数：8
相关论文
共 50 条
[1]  
Ananta JS, 2010, NAT NANOTECHNOL, V5, P815, DOI [10.1038/nnano.2010.203, 10.1038/NNANO.2010.203]
[2]   Single-molecule I2@US-tube nanocapsules:: A new X-ray contrast-agent design [J].
Ashcroft, Jared M. ;
Hartman, Keith B. ;
Kissell, Kyle R. ;
Mackeyev, Yuri ;
Pheasant, Sean ;
Young, Simon ;
Van der Heide, Paul A. W. ;
Mikos, Antoinos G. ;
Wilson, Lon J. .
ADVANCED MATERIALS, 2007, 19 (04) :573-+
[3]   Functionalization of individual ultra-short single-walled carbon nanotubes [J].
Ashcroft, Jared M. ;
Hartman, Keith B. ;
Mackeyev, Yuri ;
Hofmann, Cristina ;
Pheasant, Sean ;
Alemany, Lawrence B. ;
Wilson, Lon J. .
NANOTECHNOLOGY, 2006, 17 (20) :5033-5037
[4]   Highly functionalized carbon nanotubes using in situ generated diazonium compounds [J].
Bahr, JL ;
Tour, JM .
CHEMISTRY OF MATERIALS, 2001, 13 (11) :3823-+
[5]   Carbon nanotube actuators [J].
Baughman, RH ;
Cui, CX ;
Zakhidov, AA ;
Iqbal, Z ;
Barisci, JN ;
Spinks, GM ;
Wallace, GG ;
Mazzoldi, A ;
De Rossi, D ;
Rinzler, AG ;
Jaschinski, O ;
Roth, S ;
Kertesz, M .
SCIENCE, 1999, 284 (5418) :1340-1344
[6]   Currently used non-specific extracellular MR contrast media [J].
Bellin, MF ;
Vasile, M ;
Morel-Precetti, S .
EUROPEAN RADIOLOGY, 2003, 13 (12) :2688-2698
[7]  
Brücher E, 2002, TOP CURR CHEM, V221, P103
[8]  
CAILLE JM, 1983, AM J NEURORADIOL, V4, P1041
[9]   Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications [J].
Caravan, P ;
Ellison, JJ ;
McMurry, TJ ;
Lauffer, RB .
CHEMICAL REVIEWS, 1999, 99 (09) :2293-2352
[10]   Strategies for increasing the sensitivity of gadolinium based MRI contrast agents [J].
Caravan, Peter .
CHEMICAL SOCIETY REVIEWS, 2006, 35 (06) :512-523
12345