Flaxseed Oil Containing α-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice

被引：28

作者：

Han, Hao ^{[1
,2
,3
,4
]}

Yan, Peipei ^{[1
,2
,3
,4
]}

Chen, Li ^{[1
,2
,3
,4
]}

Luo, Cheng ^{[1
,2
,3
,4
]}

Gao, Hui ^{[1
,2
,3
,4
]}

Deng, Qianchun ^{[5
]}

Zheng, Mingming ^{[5
]}

Shi, Yong ^{[6
]}

Liu, Liegang ^{[1
,2
,3
,4
]}

机构：

[1] Huazhong Univ Sci & Technol, Sch Publ Hlth, Hubei Key Lab Food Nutr & Safety, Dept Nutr & Food Hyg,Tongji Med Coll, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Key Lab Environm & Hlth,Minist Educ, Wuhan 430030, Peoples R China

[3] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Minist Environm Protect, Wuhan 430030, Peoples R China

[4] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, State Key Lab Environm Hlth Incubating, Wuhan 430030, Peoples R China

[5] Chinese Acad Agr Sci, Hubei Univ Technol, Oil Crops Res Inst, Hubei Key Lab Oil Crops Lipid Chem & Nutr, Wuhan 430030, Peoples R China

[6] Hubei Univ Technol, Sch Food & Pharmaceut Engn, Wuhan 430030, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2015年 / 2015卷

基金：

中国国家自然科学基金;

关键词：

LIPID-METABOLISM; DENSITY-LIPOPROTEIN; HEPATIC STEATOSIS; OXIDATIVE STRESS; RISK-FACTORS; FATTY-ACIDS; CHOLESTEROL; PHYTOSTEROLS; INFLAMMATION; PROTEIN;

D O I：

10.1155/2015/958217

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Plant sterols (PS) have potential preventive function in atherosclerosis due to their cholesterol-lowering ability. Dietary alpha-linolenic acid in flaxseed oil is associated with a reduction in cardiovascular events through its hypolipidemic and anti-inflammation properties. This study was designed to evaluate the effects of flaxseed oil containing alpha-linolenic acid ester of PS (ALA-PS) on atherosclerosis and investigate the underlying mechanisms. C57BL/6 mice were administered a regular diet and apoE knockout (apoE-KO) mice were given a high fat diet alone or supplemented with 5% flaxseed oil with or without 3.3% ALA-PS for 18 weeks. Results demonstrated that flaxseed oil containing ALA-PS was synergistically interaction in ameliorating atherosclerosis as well as optimizing overall lipid levels, inhibiting inflammation and reducing oxidative stress. These data were associated with the modification effects on expression levels of genes involved in lipid metabolism (PPAR alpha, HMGCR, and SREBPs), inflammation (IL-6, TNF, MCP-1, and VCAM-1), and oxidative stress (NADPH oxidase).

引用

页数：17

共 49 条

[1] p47phox is required for atherosclerotic lesion progression in ApoE-/- mice [J].