Nanoparticle facilitated delivery of peroxides for effective cancer treatments

Through the utilization of hydrogen peroxide (H2O2) in cancer cells, nanoparticle-facilitated catalytic generation of therapeutic molecules such as O(2)and hydroxyl radicals enabled enhanced anticancer efficacy of O(2)or reactive oxygen species-dependent therapies. However, the intracellular H(2)O(2)was inadequate to obtain satisfactory therapeutic outcomes. Although several reagents such as glucose oxidase and cisplatin could promote H(2)O(2)levels by O(2)conversion, H2O2-mediated therapeutic efficacy was still hindered in the hypoxic tumor microenvironment. Fortunately, exogenous delivery of H(2)O(2)or other peroxides to tumor sites was able to break the limitation of intracellular O(2)and H(2)O(2)levels and enhance anti-tumor effects. In this review, we summarize the recent progress in constructing a peroxide delivery system for cancer treatments and discuss their challenges and potential applications.