Alkaloids from Zephyranthes robusta Baker and Their Acetylcholinesterase- and Butyrylcholinesterase-Inhibitory Activity

被引：40

作者：

Kulhankova, Andrea ^{[1
]}

Cahlikova, Lucie ^{[1
]}

Novak, Zdenek ^{[2
]}

Macakova, Katerina ^{[1
]}

Kunes, Jiri ^{[2
]}

Opletal, Lubomir ^{[1
]}

机构：

[1] Charles Univ Prague, Fac Pharm, Dept Pharmaceut Bot & Ecol, ADINACO Res Grp, CZ-50005 Hradec Kralove, Czech Republic

[2] Charles Univ Prague, Fac Pharm, Dept Inorgan & Organ Chem, CZ-50005 Hradec Kralove, Czech Republic

来源：

CHEMISTRY & BIODIVERSITY | 2013年 / 10卷 / 06期

关键词：

Zephyranthes robusta; Alzheimer's disease; Hippeastidine; Acetylcholinesterase; Butyrylcholinesterase; Inhibitors; AMARYLLIDACEAE ALKALOIDS; ANTINEOPLASTIC AGENTS; CHEMICAL-CONSTITUENTS; NARCISSUS ALKALOIDS; ALZHEIMERS-DISEASE; PROTEIN; BULBS;

D O I：

10.1002/cbdv.201200144

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The bulbs of Zephyranthes robusta (Amaryllidaceae) have been extensively analyzed for their chemical constituents, resulting in the isolation of 13 alkaloids. The chemical structures of the isolated compounds were elucidated by mass-spectrometric, and 1D- and 2D-NMR spectroscopic experiments. The complete NMR assignments were achieved for hippeastidine. All isolated alkaloids were evaluated for their erythrocytic acetylcholinesterase and serum butyrylcholinesterase inhibitory activities using the Ellman's method. Significant acetylcholinesterase inhibition activity was exhibited by 8-O-demethylmaritidine (IC50(HuAChE) 28.0 +/- 0.9M).

引用

页码：1120 / 1127

页数：8

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