Bihemispheric Transcranial Direct Current Stimulation Enhances Effector-Independent Representations of Motor Synergy and Sequence Learning

被引:111
作者
Waters-Metenier, Sheena [1 ,2 ,3 ,4 ]
Husain, Masud [1 ,2 ,3 ,4 ,5 ,6 ,7 ,8 ]
Wiestler, Tobias [1 ,2 ]
Diedrichsen, Joern [1 ,2 ]
机构
[1] UCL, Inst Cognit Neurosci, London WC1N 3AR, England
[2] UCL, Inst Cognit Neurosci, London WC1N 3BG, England
[3] UCL, Inst Neurol, London WC1N 3AR, England
[4] UCL, Inst Neurol, London WC1N 3BG, England
[5] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford OX3 9DU, England
[6] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford OX1 3UD, England
[7] Univ Oxford, Dept Expt Psychol, Oxford OX3 9DU, England
[8] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England
基金
英国惠康基金;
关键词
tDCS; motor cortex; learning; generalization; motor synergy; motor sequence; INDIVIDUATED FINGER MOVEMENTS; MODULAR ORGANIZATION; PROTEIN-SYNTHESIS; FORCE PRODUCTION; DC STIMULATION; CORTEX; STROKE; SKILL; EXCITABILITY; PERFORMANCE;
D O I
10.1523/JNEUROSCI.2282-13.2014
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Complex manual tasks-everything from buttoning up a shirt to playing the piano-fundamentally involve two components: (1) generating specific patterns of muscle activity (here, termed "synergies"); and (2) stringing these into purposeful sequences. Although transcranial direct current stimulation (tDCS) of the primary motor cortex (M1) has been found to increase the learning of motor sequences, it is unknown whether it can similarly facilitate motor synergy learning. Here, we determined the effects of tDCS on the learning of motor synergies using a novel hand configuration task that required the production of difficult muscular activation patterns. Bihemispheric tDCS was applied to M1 of healthy, right-handed human participants during 4 d of repetitive left-hand configuration training in a double-blind design. tDCS augmented synergy learning, leading subsequently to faster and more synchronized execution. This effect persisted for at least 4 weeks after training. Qualitatively similar tDCS-associated improvements occurred during training of finger sequences in a separate subject cohort. We additionally determined whether tDCS only improved the acquisition of motor memories for specific synergies/sequences or whether it also facilitated more general parts of the motor representations, which could be transferred to novel movements. Critically, we observed that tDCS effects generalized to untrained hand configurations and untrained finger sequences (i.e., were nonspecific), as well as to the untrained hand (i.e., were effector-independent). Hence, bihemispheric tDCS may be a promising adjunct to neurorehabilitative training regimes, in which broad transfer to everyday tasks is highly desirable.
引用
收藏
页码:1037 / 1050
页数:14
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