An Increase in Vascular Endothelial Growth Factor (VEGF) and VEGF Soluble Receptor-1 (sFlt-1) Are Associated with Early Recurrent Spontaneous Abortion

被引:58
作者
Pang, Lihong [1 ]
Wei, Zhouling [2 ]
Li, Ouyang [2 ]
Huang, Rudian [2 ]
Qin, Junzhen [2 ]
Chen, Hongyan [2 ]
Fan, Xiaojing [2 ]
Chen, Zi-Jiang [3 ,4 ,5 ,6 ]
机构
[1] Shandong Univ, Jinan 250100, Peoples R China
[2] GuangXi Med Univ, Affiliated Hosp 1, Nanning, Peoples R China
[3] Shandong Univ, Prov Hosp, Ctr Reprod Med, Jinan 250100, Peoples R China
[4] Natl Res Ctr Assisted Reprod Technol & Reprod Gen, Jinan, Peoples R China
[5] Minist Educ, Key Lab Reprod Endocrinol, Jinan, Peoples R China
[6] Shandong Prov Key Lab Reprod Med, Jinan, Peoples R China
来源
PLOS ONE | 2013年 / 8卷 / 09期
基金
中国国家自然科学基金;
关键词
PREECLAMPSIA; HYPERTENSION; PREGNANCY;
D O I
10.1371/journal.pone.0075759
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Recurrent spontaneous abortion (RSA) is a health problem that affects approximately 1% to 5% reproductive age woman. Yet, in around half of these patients, the mechanism for RSA is unexplained. Recent studies have indicated that placental ischemia/hypoxia and endothelial dysfunction are important factors in miscarriage. Other studies have indicated that the level and expression of soluble FMS-like tyrosine kinase-1 (sFlt1) is increased under a hypoxic environment. However, decreased sFlt-1 in the maternal circulation during the first trimester has recently been proposed as a potential marker for identifying risk of pregnancy loss. In this prospective study clinical samples were obtained within a short time after the fetal death, protein expression and maternal serum levels of sFlt1 were assessed and compared to samples taken from those with normal pregnancies. Our results indicate that levels of VEGF and sFlt-1 are both increased in women during early pregnancy compared women that are not pregnant (p<0.05) indicating that VEGF and sFlt-1 are both associated with pregnancy. More importantly, we detected a significant (p<0.05) increase in sFlt1 and VEGF levels and expression in the RSA patients who suffered subsequent miscarriages compare to controls. These results demonstrate that there is likely a relationship between VEGF, sFlt-1 and RSA suggesting that the high levels and over expression of sFlt-1 and VEGF might be associated with the pathogenesis of RSA.
引用
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页数:6
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