Effects of rare CYP2C9 alleles on stable warfarin doses in Chinese Han patients with atrial fibrillation

被引：6

作者：

Wang, Dongxu ^{[1
]}

Dai, Da-Peng ^{[2
]}

Wu, Hualan ^{[1
]}

Chong, Jia ^{[1
]}

Lu, You ^{[1
]}

Yin, Ruoyun ^{[1
]}

Zhao, Xinlong ^{[1
]}

Zhao, Anxu ^{[1
]}

Yang, Jiefu ^{[1
]}

Chen, Hao ^{[1
]}

机构：

[1] Beijing Hosp, Cardiovasc Dept, Natl Ctr Gerontol, Beijing 100730, Peoples R China

[2] Beijing Hosp, Natl Ctr Gerontol, Key Lab Geriatr, Beijing 100730, Peoples R China

来源：

PHARMACOGENOMICS | 2020年 / 21卷 / 14期

基金：

美国国家科学基金会;

关键词：

atrial fibrillation; gene polymorphism; warfarin-dosing algorithm; warfarin; GENETIC-VARIANTS; IN-VITRO; FUNCTIONAL-CHARACTERIZATION; CYP2C9-ASTERISK-13; ALLELE; GENOTYPE; VKORC1; IDENTIFICATION; REQUIREMENT; PHARMACOKINETICS; ANTICOAGULATION;

D O I：

10.2217/pgs-2020-0051

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim:Gene polymorphisms are critical in warfarin dosing variation. Here, the role of rareCYP2C9alleles on warfarin doses in Chinese Han patients was investigated.Methods:A retrospective study recruited 681 warfarin treated atrial fibrillation patients. The genetic and clinical data were collected. Dose-related variables were selected by univariate analyses and the warfarin-dosing algorithm was derived by multivariate regression analysis.Results:Three rareCYP2C9alleles (CYP2C9*13, *16 and *60) were associated with lower stable doses. Inclusion of the rareCYP2C9alleles in the prediction model added an extra 3.7% warfarin dose predictive power.Conclusion:CYP2C9*13, *16 and *60 was associated with lower stable warfarin doses in Chinese patients. The algorithm including rareCYP2C9alleles tends to more accurately predict stable warfarin doses.

引用

页码：1021 / 1031

页数：11

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