Design and demonstration of a small-animal up-conversion imager

被引：31
|
作者：
Salthouse, Christopher [1 ]
Hildebrand, Scott [1 ]
Weissleder, Ralph [1 ]
Mahmood, Umar [1 ]
机构：
[1] Massachusetts Gen Hosp, Ctr Mol Imaging Res, Charlestown, MA 02129 USA
来源：
OPTICS EXPRESS | 2008年 / 16卷 / 26期
关键词：
D O I：
10.1364/OE.16.021731
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
This first small-animal up-conversion imager (SAUCI) was developed and used for in-vivo imaging of up-converting nanoparticles (UCNs.) Unlike traditional fluorophores, UCNs absorb multiple lower-energy photons and emit a single higher-energy photon. This unique physical process makes it possible to image deeper into tissue with lower background signals. In vivo imaging of particle accumulation in the liver was demonstrated following intravenous injection of particles. (C) 2008 Optical Society of America
引用
收藏
页码：21731 / 21737
页数：7
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