A set of chiral crystal solids with odd and even numbers of carbon atoms based on S-naproxen, ester S-naproxen-R-1 (R-1 = H, methyl, ethyl, n-propyl, n-butyl, and n-amyl), has been prepared, alternatively crystallizing in the space groups P2(1) and P2(1)2(1)2(1), respectively, which shows the multi odd-even effects on cell parameters, melting points, and optical properties.