Understanding the HPV integration and its progression to cervical cancer

被引：120

作者：

Araceli Oyervides-Munoz, Mariel ^{[1
]}

Ali Perez-Maya, Antonio ^{[1
]}

Frecia Rodriguez-Gutierrez, Hazyadee ^{[1
]}

Sofia Gomez-Macias, Gabriela ^{[2
]}

Raul Fajardo-Ramirez, Oscar ^{[3
,4
,5
]}

Trevino, Victor ^{[6
]}

Alberto Barrera-Saldana, Hugo ^{[1
]}

Lourdes Garza-Rodriguez, Maria ^{[1
]}

机构：

[1] Univ Autonoma Nuevo Leon, Fac Med, Mitras Ctr, Dept Bioquim & Med Mol, Francisco I Madero & Dr E Aguirre Pequeno S-N, Monterrey 64460, NL, Mexico

[2] Univ Autonoma Nuevo Leon, Hosp Univ, Dept Anat Patol & Citopatol, Dr Jose Eleuterio Gonzalez Francisco I Madero S-N, Monterrey 64460, NL, Mexico

[3] Tecnol Monterrey, Escuela Med, Monterrey 64710, Nuevo Leon, Mexico

[4] Brigham & Womens Hosp, Ctr Excellence Vasc Biol, Dept Pathol, 75 Francis St, Boston, MA 02115 USA

[5] Harvard Med Sch, Boston, MA USA

[6] Tecnol Monterrey, Escuela Med, Catedra Bioinformat, Monterrey 64849, Nuevo Leon, Mexico

来源：

INFECTION GENETICS AND EVOLUTION | 2018年 / 61卷

关键词：

HPV; Cervical cancer; Viral integration; HUMAN-PAPILLOMAVIRUS TYPE-16; IN-SITU HYBRIDIZATION; PHYSICAL STATUS; VIRAL LOAD; PRIMARY HEAD; CASKI CELLS; COPY NUMBER; E2; GENE; DNA; GENOME;

D O I：

10.1016/j.meegid.2018.03.003

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Cervical cancer is one of the main causes of female cancer death worldwide, and human papilloma virus (HPV) its causal agent. To investigate viral oncogenesis several studies have focused on the effects of HPV oncoproteins E6 and E7 and the mechanisms by which these proteins stimulate the cellular transformation process. However, phenomena such as the physical state of the viral genome (episomal or integrated) and the effects of this integration on cell proliferation contribute new clues to understand how HPV infection causes carcinogenesis. New molecular technologies are currently facilitating these discoveries. This paper reviews the tumor development process initiated by HPV, recent findings on the process of viral integration into the host genome, new methods to detect HPV integration, and derived associated effects.

引用

页码：134 / 144

页数：11

共 98 条

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