Clonal Hematopoiesis and therapy related MDS/AML

被引：20

作者：

Desai, Pinkal ^{[1
]}

Roboz, Gail J. ^{[1
]}

机构：

[1] Weill Cornell Med, Div Hematol & Oncol, New York, NY USA

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2019年 / 32卷 / 01期

关键词：

Clonal hematopoiesis; CHIP; ARCH; Therapy related myeloid neoplasm; Therapy related MDS/AML; ACUTE MYELOID-LEUKEMIA; 2ND PRIMARY MALIGNANCIES; TP53; MUTATIONS; MYELODYSPLASTIC SYNDROME; THYROID-CANCER; INACTIVATION PATTERNS; SOMATIC MUTATIONS; COMPLEX KARYOTYPE; DNMT3A MUTATIONS; CELL;

D O I：

10.1016/j.beha.2019.02.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Clonal Hematopoiesis is defined as the presence of mutations in peripheral blood in the absence of myeloid malignancies and is thought to occur as a normal part of ageing due to the fitness advantage conferred by these mutations in an ageing hematopoietic compartment. Therapy related myeloid neoplasms are malignancies that occur after exposure to chemotherapy/radiation and are associated with poor survival. Clonal hematopoiesis mutations represent a pre malignant state that can be triggered by exposure to cytotoxic damage and rapid hematopoietic stem cell expansion. We discuss in this review clinical evidence of association of clonal hematopoiesis with risk of therapy related myeloid neoplasms, the underlying mechanisms of clonal expansion under different cellular stresses and recommendations on clinical follow up of patients with clonal hematopoiesis including possible strategies for prevention of therapy related myeloid neoplasms.

引用

页码：13 / 23

页数：11

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