Systemic T-cell activation in stable angina pectoris

被引:20
作者
Jonasson, L [1 ]
Linderfalk, C
Olsson, J
Wikby, A
Olsson, AG
机构
[1] Hogland Hosp, Res Ctr Cardiovasc & Metab Dis, Eksjo, Sweden
[2] Ryhov Hosp, Dept Microbiol, Jonkoping, Sweden
[3] Fac Hlth Sci, Dept Med & Care, Linkoping, Sweden
关键词
D O I
10.1016/S0002-9149(01)02348-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Patients with stable angina pectoris had significantly increased numbers of activated CD4+ T cells in peripheral blood compared with healthy men. The T-cell activation was further supported by significantly higher serum levels of the soluble interleukin-2 receptor. The T-cell response was more pronounced in patients who did not receive statins compared with patients on statin therapy.
引用
收藏
页码:754 / +
页数:4
相关论文
共 18 条
[1]   C-reactive protein and coronary artery disease:: Additional evidence of the implication of an inflammatory process in acute coronary syndromes [J].
Abdelmouttaleb, I ;
Danchin, N ;
Ilardo, C ;
Aimone-Gastin, I ;
Angioï, M ;
Lozniewski, A ;
Loubinoux, J ;
Le Faou, A ;
Guéant, JL .
AMERICAN HEART JOURNAL, 1999, 137 (02) :346-351
[2]   T-LYMPHOCYTE ACTIVATION IN STABLE ANGINA-PECTORIS AND AFTER PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY [J].
BLUM, A ;
SCLAROVSKY, S ;
SHOHAT, B .
CIRCULATION, 1995, 91 (01) :20-22
[3]   Evidence for antigen-driven T-cell response in unstable angina [J].
Caligiuri, G ;
Paulsson, G ;
Nicoletti, A ;
Maseri, A ;
Hansson, GK .
CIRCULATION, 2000, 102 (10) :1114-1119
[4]   Immune system activation follows inflammation in unstable angina: Pathogenetic implications [J].
Caligiuri, G ;
Liuzzo, G ;
Biasucci, LM ;
Maseri, A .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 32 (05) :1295-1304
[5]  
CUTHBERT JA, 1981, J IMMUNOL, V126, P2093
[6]   SUPPRESSION OF LYMPHOID-CELL FUNCTION-INVITRO BY INHIBITION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE BY LOVASTATIN [J].
CUTTS, JL ;
BANKHURST, AD .
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1989, 11 (08) :863-869
[7]  
FERGUSON FG, 1995, J GERONTOL A-BIOL, V50, P378
[8]  
Halme S, 1997, EUR HEART J, V18, P1095
[9]  
HANSSON GK, 1989, AM J PATHOL, V135, P169
[10]   Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin [J].
Ikonomidis, I ;
Andreotti, F ;
Economou, E ;
Stefanadis, C ;
Toutouzas, P ;
Nihoyannopoulos, P .
CIRCULATION, 1999, 100 (08) :793-798