Immunoadhesins as research tools and therapeutic agents

被引：57

作者：

Ashkenazi, A ^{[1
]}

Chamow, SM ^{[1
]}

机构：

[1] GENENTECH INC, DEPT RECOVERY SERV, San Francisco, CA 94080 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(97)80135-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An immunoadhesin is a fusion protein that combines the target-binding region of a receptor, an adhesion molecule, a ligand, or an enzyme, with the Fc region of an Ig. Immunoadhesins provide a unique tool for identifying unknown binding targets and for elucidating molecular interactions that control biological function. Recent studies suggest that immunoadhesins also may be useful therapeutically, as inhibitors of autoimmune and inflammatory diseases.

引用

页码：195 / 200

页数：6

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