Treatment of hyperthyroidism in Down syndrome: Case report and review of the literature

Thyroid disorders are common in individuals with Do,vn syndrome (DS). Hyper thyroidism occurs much less frequently than hypothyroidism in this population, but is likely to be underestimated. We report a case of an institutionalized adult male with DS and hyperthyroidism. Ne was treated with radioactive iodine aid when reviewed II weeks later was found to be markedly hypothyroid. We also review the literature on the three treatment options for hyperthyroidism in DS: surgery medical treatment, and radiotherapy. We concluded that the place of radioiodine in the treatment of hyperthyroid patients with DS is yet to be defined. (C) 1999 Elsevier Science Ltd.