Are hypomineralised lesions on second primary molars (HSPM) a predictive sign of molar incisor hypomineralisation (MIH)? A systematic review and a meta-analysis

Objectives: Molar Incisor Hypomineralisation (MIH) and Hypomineralised Second Primary Molars (HSPM) involve qualitative structural developmental anomalies of tooth enamel affecting the first permanent molars (and often incisors) and the second primary molars, respectively. A putative relationship between HSPM and MIH has been reported in the scientific literature. The aim was to determine whether children with HSPM are more likely to develop MIH. Source: A systematic search using PubMed/Medline, Embase and Cochrane Library electronic databases for publications from 2001 to August 2017 investigating the link between MIH and HSPM was undertaken. Study selection: Four reviewers selected the studies independently, extracted the data according to PRISMA statement, and assessed the bias risk with the Newcastle-Ottawa Scale (NOS) criteria. Results: From 645 potentially eligible studies, 14 were selected for full text analysis and 5 were included in the meta-analysis. Cross-sectional and cohort studies were reported and 4662 participants were included. The meta-analyses were performed with a random model calculated an OR total of 4.66 (95% CI 2.11-10.26; P < 0.001). The weighted mean of the co-occurrence of HSPM and MIH prevalence was 19.94%. Discussion: The high heterogeneity (I-2 = 88%) can be explained by the great variation present in number of participants and variable caries risk. Despite the limitations of the study, the presence of HSPM is predictive for MIH, with greater MIH prevalence in the presence of mild HSPM. Clinical significance: Early detection and preventive intervention could reduce MIH complications.