Function and dysfunction of two-pore channels

被引：124

作者：

Patel, Sandip ^{[1
]}

机构：

[1] UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

来源：

SCIENCE SIGNALING | 2015年 / 8卷 / 384期

基金：

英国生物技术与生命科学研究理事会;

关键词：

ADENINE-DINUCLEOTIDE PHOSPHATE; VOLTAGE-GATED SODIUM; ION-CHANNEL; MOBILIZES CALCIUM; RELEASE CHANNEL; TPC PROTEINS; NAADP; CA2+; ISOFORMS; DISEASE;

D O I：

10.1126/scisignal.aab3314

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two-pore channels (TPCs) are evolutionarily important members of the voltage-gated ion channel superfamily. TPCs localize to acidic Ca2+ stores within the endolysosomal system. Most evidence indicate that TPCs mediate Ca2+ signals through the Ca2+-mobilizing messenger nicotinic acid adenine dinucleotide phosphate (NAADP) to control a range of Ca2+-dependent events. Recent studies clarify the mechanism of TPC activation and identify roles for TPCs in disease, highlighting the regulation of endolysosomal membrane traffic by local Ca2+ fluxes. Chemical targeting of TPCs to maintain endolysosomal "well-being" may be beneficial in disorders as diverse as Parkinson's disease, fatty liver disease, and Ebola virus infection.

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页数：6

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