NRAMP1 and VDR Gene Polymorphisms in Susceptibility to Tuberculosis in Venezuelan Population

被引:25
作者
Fernandez-Mestre, Mercedes [1 ]
Villasmil, Angel [1 ]
Takiff, Howard [2 ]
Fuentes Alcala, Zhenia [3 ]
机构
[1] Inst Venezolano Invest Cient, Ctr Med Expt Miguel Layrisse, Lab Fisiopatol, Caracas 1020A, Distrito Capita, Venezuela
[2] Inst Venezolano Invest Cient, Genet Mol Lab, Ctr Microbiol & Biol Celular, Caracas 1020A, Distrito Capita, Venezuela
[3] Hosp Dr Jose Ignacio Baldo El Algodonal, Unidad Torax, Caracas 1020A, Distrito Capita, Venezuela
关键词
D-RECEPTOR POLYMORPHISMS; PULMONARY TUBERCULOSIS; MYCOBACTERIUM-TUBERCULOSIS; ASSOCIATION; RESISTANCE; INFECTION; VARIANTS; FOKI; BSMI; APAI;
D O I
10.1155/2015/860628
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Natural resistance-associated macrophage protein (Nramp1) and the vitamin D receptor (VDR) are central components of the innate and adaptive immunity against Mycobacterium tuberculosis, and associations between susceptibility to tuberculosis and polymorphisms in the genes NRAMP and VDR have been sought in geographically diverse populations. We investigated associations of NRAMP1 and VDR gene polymorphisms with susceptibility to TB in the Venezuelan population. The results suggest the absence of any association between VDR variants FokI, ApaI, and TaqI and susceptibility to tuberculosis. In contrast, the NRAMP1 3'UTR variants were associated with susceptibility to M. tuberculosis infection, as seen in the comparisons between TST+ and TST - controls, and also with progression to TB disease, as shown in the comparisons between TB patients and TST+ controls. This study confirms the previously described association of the NRAMP1 3'UTR polymorphism with M. tuberculosis infection and disease progression.
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页数:7
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