The Endocannabinoid System in Energy Homeostasis and the Etiopathology of Metabolic Disorders

被引：419
作者：
Silvestri, Cristoforo [1 ]
Di Marzo, Vincenzo [1 ]
机构：
[1] CNR, Inst Biomol Chem, Endocannabinoid Res Grp, I-80078 Pozzuoli, NA, Italy
来源：
CELL METABOLISM | 2013年 / 17卷 / 04期
关键词：
CANNABINOID CB1 RECEPTOR; ACTIVATED PROTEIN-KINASE; SUBCUTANEOUS ADIPOSE-TISSUE; ACID AMIDE HYDROLASE; HIGH-FAT DIET; FOOD-INTAKE; ANTAGONIST RIMONABANT; INSULIN-RESISTANCE; SKELETAL-MUSCLE; WEIGHT-LOSS;
D O I：
10.1016/j.cmet.2013.03.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Endocannabinoids and cannabinoid CB1 receptors are known to play a generalized role in energy homeostasis. However, clinical trials with the first generation of CB1 blockers, now discontinued due to psychiatric side effects, were originally designed to reduce food intake and body weight rather than the metabolic risk factors associated with obesity. In this review, we discuss how, in addition to promoting energy intake, endocannabinoids control lipid and glucose metabolism in several peripheral organs, particularly the liver and adipose tissue. Direct actions in skeletal muscle and pancreas are also emerging. This knowledge may help in the design of future therapies for the metabolic syndrome.
引用
收藏
页码：475 / 490
页数：16
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