Hard and soft tissue changes around implants activated using plasma of argon: A histomorphometric study in dog

被引:26
作者
Canullo, Luigi [1 ]
Tallarico, Marco [1 ]
Botticelli, Daniele [2 ]
Alccayhuaman, Karol Ali Apaza [2 ]
Martins Neto, Evandro Carneiro [3 ]
Xavier, Samuel Porfirio [3 ]
机构
[1] Private Practice, Rome, Italy
[2] ARDEC Acad, Ariminum Odontol, Rimini, Italy
[3] Univ Sao Paulo, Fac Ribeirao Preto, Depto CTBMF & Periodontia FORP, Ribeirao Preto, Brazil
关键词
animal experiments; BIC; bone implant interactions; dental implant; plasma of argon; DEPENDENT DEGRADATION; PROTEIN ADSORPTION; BONE APPOSITION; CELL BEHAVIOR; SURFACES; TITANIUM; OSSEOINTEGRATION; HYDROPHILICITY; ENERGY;
D O I
10.1111/clr.13134
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
ObjectiveTo histologically assess the hard and soft tissue changes after insertion of cleaned and activated titanium implants using plasma of argon. Materials and methodsEight dogs were included in this study. The mandibular premolars and first molars were extracted. For each hemi-mandible, four implants, 7mm long and 3.3mm of diameter, with a ZirTi surface were used. The surface of two implants was randomly treated with argon plasma (test), while the other two implants were left untreated (control). After 1month, the same procedure was performed in the contralateral hemi-mandible. The amount of old bone, new bone, overall value of old bone plus new bone, and soft tissue was histologically evaluated. ResultsAfter 1month of healing, high percentages of new bone in close contact with the implant surface were found at both the treated (60.1%15.6%; 95% CI 56.5%-78.0%) and untreated (57.2%+/- 13.1%; 95% CI 49.3%-67.5%) implants. Low percentages of old bone were found at this stage of healing, at both the treated (4.4%+/- 3.0%; 95% CI 1.2%-5.4%) and untreated (3.4%+/- 3.1%; 95% CI 0.6%-4.9%) implants. Not statistically significant differences were found between groups (p>.05). After 2months of healing, treated implants presented a significantly higher (p=.012) new bone formation (72.5%+/- 12.4%; 95% CI 69.6%-86.8%) compared to untreated sites (64.7%+/- 17.3%; 95% CI 59.4%-83.3%). Controversially, no difference (p=.270) in terms of old bone was present between treated (3.1%+/- 1.7%, 95% CI 1.8%-4.2%) and untreated implants (3.8%+/- 1.9%, 95% CI 3.2%-5.8%). Significant differences (p=.018) in terms of total mineralized bone were found between treated (75.6%+/- 13.0%, 95% CI 73.3%-91.3%) and untreated implants (68.4%+/- 16.8%; 95% CI 64.2%-87.6%). ConclusionsImplants treated using plasma of argon was demonstrated to reach a higher bone-to-implant contact when compared to untreated implants.
引用
收藏
页码:389 / 395
页数:7
相关论文
共 27 条
[1]   Osteoinduction, osteoconduction and osseointegration [J].
Albrektsson, T ;
Johansson, C .
EUROPEAN SPINE JOURNAL, 2001, 10 (Suppl 2) :S96-S101
[2]   THE INTERFACE ZONE OF INORGANIC IMPLANTS INVIVO - TITANIUM IMPLANTS IN BONE [J].
ALBREKTSSON, T ;
BRANEMARK, PI ;
HANSSON, HA ;
KASEMO, B ;
LARSSON, K ;
LUNDSTROM, I ;
MCQUEEN, DH ;
SKALAK, R .
ANNALS OF BIOMEDICAL ENGINEERING, 1983, 11 (01) :1-27
[3]  
Aronsson BO, 1997, J BIOMED MATER RES, V35, P49
[4]   Time-dependent degradation of titanium osteoconductivity: An implication of biological aging of implant materials [J].
Atta, Wael ;
Hori, Norio ;
Takeuchi, Masato ;
Ouyang, Jianyong ;
Yang, Yang ;
Anpo, Masakazu ;
Ogawa, Takahiro .
BIOMATERIALS, 2009, 30 (29) :5352-5363
[5]   The role of bone debris in early healing adjacent to hydrophilic and hydrophobic implant surfaces in man [J].
Bosshardt, Dieter D. ;
Salvi, Giovanni E. ;
Huynh-Ba, Guy ;
Ivanovski, Saso ;
Donos, Nikolaos ;
Lang, Niklaus P. .
CLINICAL ORAL IMPLANTS RESEARCH, 2011, 22 (04) :357-364
[6]   Dynamics of osseointegration in various human and animal models - a comparative analysis [J].
Botticelli, Daniele ;
Lang, Niklaus P. .
CLINICAL ORAL IMPLANTS RESEARCH, 2017, 28 (06) :742-748
[7]   Enhanced bone apposition to a chemically modified SLA titanium surface [J].
Buser, D ;
Broggini, N ;
Wieland, M ;
Schenk, RK ;
Denzer, AJ ;
Cochran, DL ;
Hoffmann, B ;
Lussi, A ;
Steinemann, SG .
JOURNAL OF DENTAL RESEARCH, 2004, 83 (07) :529-533
[8]   Plasma of Argon Affects the Earliest Biological Response of Different Implant Surfaces: An In Vitro Comparative Study [J].
Canullo, L. ;
Genova, T. ;
Tallarico, M. ;
Gautier, G. ;
Mussano, F. ;
Botticelli, D. .
JOURNAL OF DENTAL RESEARCH, 2016, 95 (05) :566-573
[9]   Argon-based atmospheric pressure plasma enhances early bone response to rough titanium surfaces [J].
Coelho, Paulo G. ;
Giro, Gabriela ;
Teixeira, Hellen S. ;
Marin, Charles ;
Witek, Lukas ;
Thompson, Van P. ;
Tovar, Nick ;
Silva, Nelson R. F. A. .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2012, 100A (07) :1901-1906
[10]   Basic Research Methods and Current Trends of Dental Implant Surfaces [J].
Coelho, Paulo G. ;
Granjeiro, Jose M. ;
Romanos, George E. ;
Suzuki, Marcelo ;
Silva, Nelson R. F. ;
Cardaropoli, Giuseppe ;
Thompson, Van P. ;
Lemons, Jack E. .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2009, 88B (02) :579-596