Immunomodulatory action of mycobacterial secretory proteins

被引：34
作者：
Trajkovic, V
Natarajan, K
Sharma, P [1 ]
机构：
[1] ICGEB, Immunol Grp, New Delhi 110067, India
[2] Univ Belgrade, Sch Med, Inst Microbiol & Immunol, YU-11000 Belgrade, Serbia
来源：
MICROBES AND INFECTION | 2004年 / 6卷 / 05期
关键词：
Mycobacterium tuberculosis; tuberculosis; immunity; immunomodulation;
D O I：
10.1016/j.micinf.2003.12.015
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The recently discovered RD1 locus encodes proteins that are actively secreted by pathogenic mycobacteria, including Mycobacterium tuberculosis. Since they are missing in non-tuberculous mycobacteria, these proteins are promising not only as candidates for vaccination and diagnostic tests, but also in understanding mycobacterial evasion of protective immunity in susceptible individuals. Here we analyze the possible role of M. tuberculosis secretory proteins in immunity against tuberculosis, with emphasis on their immunomodulatory action and the potential involvement in mycobacterial subversion of the host immune defense. (C) 2004 Elsevier SAS. All rights reserved.
引用
收藏
页码：513 / 519
页数：7
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