Studies toward synthesis of the core skeleton of spiroaspertrione A

被引：1

作者：

Shen, Zhong-Hui ^{[1
]}

Lu, Si-Yuan ^{[1
]}

Zheng, Jing-Yun ^{[1
]}

Zhang, Xiang-Zhi ^{[1
]}

Peng, Jin-Bao ^{[1
]}

Ma, Ai-Jun ^{[1
]}

机构：

[1] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen, Peoples R China

来源：

FRONTIERS IN CHEMISTRY | 2022年 / 10卷

关键词：

studies; synthesis; core skeleton; spiroaspertrione A; natural product; RESISTANT STAPHYLOCOCCUS-AUREUS; ENANTIOSELECTIVE TOTAL-SYNTHESIS; CARBONYL-COMPOUNDS; MECHANISM; INDOLE; KETONE; ACIDS; SCOPE;

D O I：

10.3389/fchem.2022.1022533

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bioassay-guided isolation of spiroaspertrione A from cultures of Aspergillus sp. TJ23 in 2017 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold. To construct this unique spiro[bicyclo[3.2.2]nonane-2,1 & PRIME;-cyclohexane] system, a protocol for ceric ammonium nitrate-induced intramolecular cross-coupling of silyl enolate is disclosed.

引用

页数：8

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