Networking galore: intermediate filaments and cell migration

被引：146

作者：

Chung, Byung-Min ^{[1
]}

Rotty, Jeremy D. ^{[1
]}

Coulombe, Pierre A. ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD 21205 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2013年 / 25卷 / 05期

基金：

美国国家卫生研究院;

关键词：

KERATIN FILAMENTS; EPITHELIAL-CELLS; DOWN-REGULATION; CANCER-CELLS; POSTTRANSLATIONAL MODIFICATIONS; EXPERIMENTAL COEXPRESSION; VIMENTIN CONTRIBUTES; INHIBITS GROWTH; SIZED FILAMENTS; EXPRESSION;

D O I：

10.1016/j.ceb.2013.06.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Intermediate filaments (IFs) are assembled from a diverse group of evolutionarily conserved proteins and are specified in a tissue-dependent, cell type-dependent, and context-dependent fashion in the body. IFs are involved in multiple cellular processes that are crucial for the maintenance of cell and tissue integrity and the response and adaptation to various stresses, as conveyed by the broad array of crippling clinical disorders caused by inherited mutations in IF coding sequences. Accordingly, the expression, assembly, and organization of IFs are tightly regulated. Migration is a fitting example of a cell-based phenomenon in which IFs participate as both effectors and regulators. With a particular focus on vimentin and keratin, we here review how the contributions of IFs to the cell's mechanical properties, to cytoarchitecture and adhesion, and to regulatory pathways collectively exert a significant impact on cell migration.

引用

页码：600 / 612

页数：13

共 113 条

[1] Loss of Keratin 8 Phosphorylation Leads to Increased Tumor Progression and Correlates with Clinico-Pathological Parameters of OSCC Patients [J].